cam a22 4500 282806512 CHVBK 20200927173406.0 cr || |||||||| 130818s2009 sz sm 00 0 eng d urn:nbn:ch:bel-297278 urn 10.5167/uzh-32229 doi (SNL)991017984302303976 (NEBIS)005864708 (ZORA)oai:www.zora.uzh.ch:32229 (Sz)991017984302303976 (Sz)001714351 Sz Sz 630 23sdnb 570 ddc 630 ddc Major Andrea Claudia Exposure of cats to low doses of FeLV seroconversion as the sole parameter of infection von Andrea Claudia Major [S.l.] [s.n.] 2009 30 S. Ill. Titel und Beschreibung vom Lieferanten (15.07.2013) Diss. Univ. Zürich, 2009 openAccess eu-repo application/pdf In felids, Feline Leukemia Virus (FeLV) infection results in a variety of outcomes that range from abortive to progressive infection. Recently, a novel outcome was postulated for low FeLV infectious doses. Naïve cats exposed to faeces of persistently infected cats seroconverted, indicating infection, but remained negative for provirus and p27 antigen in blood. FeLV provirus was found in some tissues but not in the bone marrow, infection of which is usually considered a necessary stage for disease progression. To investigate the impact of low FeLV doses on young cats and to test our hypothesis that low dose exposure may lead to an unknown pathogenesis of infection without involvement of the bone marrow, 21 cats were infected oronasally with variable viral doses. Blood p27, proviral and viral loads were followed until week 20 post-infection. Tissue proviral loads were determined as well. The immune response was monitored by FeLV whole virus and p45 ELISA, FOCMA assay and Western blot. One cat showed regressive infection. In 7 cats, FOCMA assay positivity was the only sign of infection. Provirus was only found in some organs of the regressively infected cat. Here, we show that FeLV low dose exposure can result in seroconversion during a presumed abortive infection. Therefore, commonly used detection methods do not cover the whole spectrum of FeLV pathogenesis, leading to a possible underestimation of the effective occurrence of infection in the cat population Hochschulschrift gnd-content Department of Farm Animals zora UZH Dissertations zora xehelv xediss 2013 630 snl ehelv SNL NB001 NB999 - chb99 - http://opac.nebis.ch/ediss/20090617_002366098.pdf https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-297278 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-297278 BK020353 XK020053 XK020000 1 Hochschulschrift = Thèse/Mémoire 2 CF Elektron. Daten Fernzugriff=Fichier online UNI-ZH nebis E2 ZH idszbz Z1 zbzdis200908e knec zbzswk200908d idszbz Z2 Dissertation Veterinärmedizinisches Labor idsuzh U ZB636 Z01 ZORA ZORA ZORA Dissertation openAccess NEBIS Z01 Z01 ADH DAR DD 2068 NEBIS Z01 Z01 05 UnS 2009: 179 NEBIS Z01 Z01 OL NEBIS UVET UVET ULVET VetB Diss ZH 2009 SNL 100 1- Major Andrea Claudia SNL 856 40 http://opac.nebis.ch/ediss/20090617_002366098.pdf SNL 856 4- https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-297278 SNL 856 42 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-297278 NEBIS 100 1- Major Andrea Claudia NEBIS 700 1- Lutz Hans 1946- (DE-588)1089103921 Akademischer Betreuer dgs ZORA 856 40 https://www.zora.uzh.ch/id/eprint/32229/1/Exposure1.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Major A. NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/objects/pdf/z01_005864708_01.pdf Titelblatt und Inhaltsverzeichnis VIEW pdf NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/F?func=service&doc_library=EBI01&local_base=EBI01&doc_number=005864708&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Volltext VIEW pdf 20090617_002366098.pdf NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/ediss/20090617_a_002366100.pdf Abstract VIEW pdf SWISSBIB 282806512 ORANGE 282806512