cam a22 4500 282811044 CHVBK 20200918090726.0 cr || |||||||| 130818s2007 sz sm 00 0 eng d urn:nbn:ch:bel-279586 urn 10.5167/uzh-4806 doi (SNL)991017984243503976 (NEBIS)005426826 (ZORA)oai:www.zora.uzh.ch:4806 (Sz)991017984243503976 (Sz)001704957 Sz Sz 630 23sdnb 570 ddc Clement Flurina Christina Expression signature of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide von Flurina Christina Clement [S.l.] [s.n.] 2007 50 S. Ill. Titel und Beschreibung vom Lieferanten (05.04.2013) Diss. Univ. Zürich, 2007 openAccess eu-repo application/pdf Recent findings of acrylamide in foods have sparked renewed interest in assessing human health hazards associated with the exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents, but cancer risk projections in the human population remain problematic since the molecular pathogenesis of acrylamide at the low level of dietary uptake is not understood. The present thesis is concerned with the question of whether transcriptional responses may amplify the known genotoxicity of acrylamide. Therefore, we used high-density DNA microarrays and PCR validations to assess genomewide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the glutathione system, carbonyl reductases and various antioxidants. Low-dose experiments indicate that epoxide hydrolase 1 represents the most sensitive biomarker for the internal glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression such as steroid hormone activators, regulators of nuclear factor-κB, growth stimulators and apoptosis inhibitors. Concomitantly, growth suppressors and cell adhesion molecules are suppressed. The main implication of these findings for risk assessment is that transcriptional signatures associated with tumor cell progression may be expected only at higher doses that exceed the range of ordinary dietary exposure. Hochschulschrift gnd-content Institute of Veterinary Pharmacology and Toxicology zora UZH Dissertations zora xehelv xediss 2013 630 snl ehelv SNL NB001 NB999 - chb99 - http://opac.nebis.ch/ediss/20070135.pdf https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-279586 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-279586 BK020353 XK020053 XK020000 1 Hochschulschrift = Thèse/Mémoire 2 CF Elektron. Daten Fernzugriff=Fichier online UNI-ZH nebis E2 ZH idszbz Z1 zbzdis200709e knec zbzswk200709d idszbz Z2 ZB636 Z01 ZORA ZORA ZORA Dissertation openAccess NEBIS Z01 Z01 ADH DAR DD 1938 NEBIS Z01 Z01 05 UnS 2007: 226 NEBIS Z01 Z01 OL SNL 100 1- Clement Flurina Christina SNL 856 40 http://opac.nebis.ch/ediss/20070135.pdf SNL 856 4- https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-279586 SNL 856 42 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-279586 NEBIS 100 1- Clement Flurina Christina NEBIS 700 1- Nägeli Hanspeter 1960- (DE-588)108927887X Akademischer Betreuer dgs ZORA 856 40 https://www.zora.uzh.ch/id/eprint/4806/12/DissClement2007V.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Clement F C. NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/F?func=service&doc_library=EBI01&local_base=EBI01&doc_number=005426826&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Volltext VIEW pdf 20070135.pdf NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/ediss/20070135_a.pdf Abstract VIEW pdf SWISSBIB 282811044 ORANGE 282811044