cad a22 4500 316949566 20181103043304.0 cr unu---uuuuu 140620s1985 xx s 000 0 ger 10.5167/uzh-96604 doi 10.1002/hlca.19850680220 doi (ZORA)oai:www.zora.uzh.ch:96604 540 ddc Obrecht Daniel Synthese von 3,3-Dimethylperhydro-1,4-diazepin-2,5,7-trionen aus 3-Dimethylamino-2,2-dimethyl-2H-azirin und Malonsäuremonoamiden [Elektronische Daten] [Daniel Obrecht, Bernhard Scholl, Heinz Heimgartner] closedAccess eu-repo Reaction of the aminoazirine 1 and malonic acid monoamides 5 in CH3CN yielded triamides of type 6 (Scheme 2), which were transformed to the corresponding phenylthioates 9 by treatment of a solution of 6 and thiophenol in CH3CN with HCI (Scheme 4). Cyclization of 9 to give the 1,4-diazepin-2,5,7-trione of type 10 was achieved with NaH in toluene at about 90°. It has been shown that 2-oxazolin-5-ones are intermediates in the selective cleavage of the terminal amide function of 6 (Scheme 3 ) . Department of Chemistry zora Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Biochemistry, Drug Discovery, Catalysis zora Scholl Bernhard joint author Heimgartner Heinz joint author Helvetica Chimica Acta 68(2):465-474 https://www.zora.uzh.ch/id/eprint/96604/1/92_Obrecht_HCA_1985.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/96604/1/92_Obrecht_HCA_1985.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Obrecht Daniel ZORA 700 1- Scholl Bernhard joint author ZORA 700 1- Heimgartner Heinz joint author ZORA 773 0- Helvetica Chimica Acta 68(2):465-474 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article closedAccess