cad a22 4500 316949787 20181103043304.0 cr unu---uuuuu 140620e201405 xx s 000 0 eng 10.5167/uzh-96638 doi 10.1136/bmjopen-2013-004357 doi (ZORA)oai:www.zora.uzh.ch:96638 610 ddc 24848086 pmid Protocol for a prospective neuroimaging study investigating the supraspinal control of lower urinary tract function in healthy controls and patients with non-neurogenic lower urinary tract symptoms [Elektronische Daten] [Matthias Walter, Lars Michels, Spyros Kollias, Philip E van Kerrebroeck, Thomas M Kessler, Ulrich Mehnert] openAccess eu-repo INTRODUCTION: Lower urinary tract symptoms (LUTS) are highly prevalent, cause an enormous economic burden on healthcare systems and significantly impair the quality of life (QoL) of affected patients. The dependence of the LUT on complex central neuronal circuits makes it unique in comparison to other visceral functions, such as the gastrointestinal tract, but also more vulnerable to neurological diseases. METHODS AND ANALYSIS: This is a prospective neuroimaging study investigating the supraspinal control of LUT function in healthy controls and in patients with non-neurogenic LUTS. The clinical assessment will include medical history, neuro-urological examination, bladder diary, urine analysis, urodynamic investigations, as well as standardised questionnaires regarding LUTS and QoL. The acquisition of neuroimaging data will include structural assessments (T1-weighted imaging and diffusion tensor imaging) as well as functional investigations using blood-oxygen-level dependent sensitive functional MRI (fMRI) in a 3 T MR scanner. The fMRI will be performed during four different bladder tasks using an automated MR-compatible and MR-synchronised pump system. The first three task-related fMRIs will consist of automated, repetitive filling of 100 mL warm (37°C) saline starting with (1) an empty bladder, (2) a low prefilled bladder volume (100 mL) and (3) a high prefilled bladder volume (persistent desire to void). The fourth task-related fMRI will comprise of automated, repetitive filling of 100 mL cold (4-8°C) saline starting with an empty bladder. ETHICS AND DISSEMINATION: The local ethics committee approved this study (KEK-ZH-Nr. 2011-0346). The findings of the study will be published in peer-reviewed journals and presented at national and international scientific meetings. TRIAL REGISTRATION NUMBER: This study has been registered at clinicaltrials.gov (http://www.clinicaltrials.gov/ct2/show/NCT01768910). Medical Clinic zora Clinic for Neuroradiology zora Balgrist University Hospital, Swiss Spinal Cord Injury Center zora Walter Matthias joint author Michels Lars joint author Kollias Spyros joint author van Kerrebroeck Philip E. joint author Kessler Thomas M. joint author Mehnert Ulrich joint author BMJ Open 4(5):e004357 https://www.zora.uzh.ch/id/eprint/96638/1/BMJ_Open-2014-Walter-.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/96638/1/BMJ_Open-2014-Walter-.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Walter Matthias joint author ZORA 700 1- Michels Lars joint author ZORA 700 1- Kollias Spyros joint author ZORA 700 1- van Kerrebroeck Philip E. joint author ZORA 700 1- Kessler Thomas M. joint author ZORA 700 1- Mehnert Ulrich joint author ZORA 773 0- BMJ Open 4(5):e004357 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess