cad a22 4500 317037102 20181103043235.0 cr unu---uuuuu 140621s2014 xx s 000 0 eng 10.5167/uzh-95135 doi 10.2460/ajvr.75.4.361 doi (ZORA)oai:www.zora.uzh.ch:95135 570 ddc 610 ddc 24669921 pmid High-resolution manometric evaluation of the effects of cisapride and metoclopramide hydrochloride administered orally on lower esophageal sphincter pressure in awake dogs [Elektronische Daten] [Jennifer Kempf, Fraser Lewis, Claudia E Reusch, Peter H Kook] closedAccess eu-repo Objective-To evaluate the effects of cisapride and metoclopramide hydrochloride administered orally on the lower esophageal sphincter (LES) resting pressure in awake healthy dogs. Animals-6 adult Beagles. Procedures-Each dog was evaluated after administration of a single dose of cisapride (0.5 mg/kg), metoclopramide (0.5 mg/kg), or placebo (empty gelatin-free capsule) in 3 experiments performed at 3-week intervals. To measure LES pressure, a high-resolution manometry catheter equipped with 40 pressure sensors spaced 10 mm apart was used. For each experiment, LES pressure was recorded during a 20-minute period with a virtual electronic sleeve emulation before treatment (baseline) and at 1, 4, and 7 hours after drug or placebo administration. A linear mixed-effects model was used to test whether the 3 treatments affected LES pressure differently. Results-In the cisapride, metoclopramide, and placebo experiments, median baseline LES pressures were 29.1, 30.5, and 29.0 mm Hg, respectively. For the cisapride, metoclopramide, and placebo treatments, median LES pressures at 1 hour after administration were 44.4, 37.8, and 36.6 mm Hg, respectively; median LES pressures at 4 hours after administration were 50.7, 30.6, and 31.1 mm Hg, respectively; and median LES pressures at 7 hours after administration were 44.3, 28.5, and 33.3 mm Hg, respectively. The LES pressures differed significantly only between the placebo and cisapride treatments. Conclusions and Clinical Relevance-Results suggested that orally administered cisapride may be of benefit in canine patients for which an increase in LES pressure is desirable, whereas orally administered metoclopramide did not affect LES resting pressures in dogs. Chair in Veterinary Epidemiology zora Department of Small Animals zora Kempf Jennifer joint author Lewis Fraser joint author Reusch Claudia E. joint author Kook Peter H. joint author American Journal of Veterinary Research 75(4):361-366 https://www.zora.uzh.ch/id/eprint/95135/1/Kempf_AJVR_2014.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/95135/1/Kempf_AJVR_2014.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Kempf Jennifer joint author ZORA 700 1- Lewis Fraser joint author ZORA 700 1- Reusch Claudia E. joint author ZORA 700 1- Kook Peter H. joint author ZORA 773 0- American Journal of Veterinary Research 75(4):361-366 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article closedAccess