cam a22 7 4500 317151606 CHVBK 20200927175120.0 cr ## ######## 140625s2014 sz sm 00 0 eng d urn:nbn:ch:bel-401074 urn 10.5167/uzh-164327 doi (SNL)991017979118703976 (NEBIS)010161011 (ZORA)oai:www.zora.uzh.ch:164327 (Sz)991017979118703976 (Sz)001758484 Sz Sz 630 23sdnb 570 ddc Bachmann Samia Beatrice 1989- (DE-588)1116493802 Functional roles of DTX3L and ARTD9 in prostate cancer von Samia Beatrice Bachmann [S.l.] [s.n.] 2014 50 S. Ill. Titel und Beschreibung vom Lieferanten (09.09.2014) Diss. Univ. Zürich, 2014 openAccess eu-repo application/pdf Prostate cancer (PCa) is one of the leading causes of cancer related mortality and morbidity in the aging male population. The B-lymphoma and BAL-associated protein (BBAP) and Deltex (DTX)-3-like E3 ubiquitin ligase (DTX3L), was originally identified as a binding partner of the B-aggressive lymphoma-1 protein and diphtheria-toxin-like ADP-ribosyltransferase-9 (BAL1/ARTD9). Here it is shown, that DTX3L and ARTD9 are both overexpressed in PCa cells. Together with ARTD8 (ADP-ribosyltransferase-8) they mediate proliferation, survival and chemo-resistance of PCa cells. The effects of DTX3L and ARTD9 are dependent on the signal transducer and activator of transcription factor 1 (STAT-1). STAT-1 is known as a tumor suppressor, activated by interferon γ (IFNγ). Its antitumor effects are mainly based on the activation of the transcription of the interferon responding factor 1 (IRF1). New reports showed that a constitutively activated STAT-1 leads to an IFNγ- and chemo-resistance of tumors and acts as an oncogene. Such a situation occurred also in the analyzed PCa cells. The presented study shows that DTX3L and ARTD9 repress the expression of IRF1. DTX3L also mediates migration of PCa cells in a STAT-1 and STAT-3-dependent manner. However, migration is not dependent on IFNy/IRF1. Together, this study suggests that the combined inhibition of STAT-1, ARTD8, ARTD9 and/or DTX3L could increase the efficacy of chemotherapy or radiation treatment in prostate cancer Hochschulschrift gnd-content Institute of Veterinary Physiology zora Department of Molecular Mechanisms of Disease zora UZH Dissertations zora DTX3L, ARTD9, prostate cancer, proliferation, migration zora xehelv xediss 2014 630 snl ehelv SNL NB001 NB999 - chb99 - http://opac.nebis.ch/ediss/20142030.pdf https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-401074 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-401074 BK020353 XK020053 XK020000 1 Hochschulschrift = Thèse/Mémoire 2 CF Elektron. Daten Fernzugriff=Fichier online Dissertation Vetsuisse-Fakultät idsuzh U Dissertation Institut für Veterinärbiochemie und Molekularbiologie idsuzh U UVET-201406 nebis EN UNI-ZH nebis E2 ZH idszbz Z1 zbzdis201406e wuet zbzswk201406d idszbz Z2 ZB636 Z01 ZORA ZORA ZORA Dissertation openAccess NEBIS Z01 Z01 ADH DAR DD 2363 NEBIS Z01 Z01 05 UnS 2014: 725 NEBIS Z01 Z01 OL NEBIS UVET UVET ULVET VetB Diss ZH 2014 SNL 100 1- Bachmann Samia Beatrice 1989- (DE-588)1116493802 SNL 856 40 http://opac.nebis.ch/ediss/20142030.pdf SNL 856 4- https://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:bel-401074 SNL 856 42 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-401074 NEBIS 100 1- Bachmann Samia Beatrice 1989- (DE-588)1116493802 NEBIS 700 1- Hottiger Michael 1966- (DE-588)108930238X Akademischer Betreuer dgs ZORA 856 40 https://www.zora.uzh.ch/id/eprint/164327/1/20142030.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Bachmann Samia Beatrice NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/F?func=service&doc_library=EBI01&local_base=EBI01&doc_number=010161011&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Volltext VIEW pdf 20142030.pdf NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/ediss/20142030_a.pdf Abstract VIEW pdf NEBIS ZAD50 EBI01 Z01 https://opac.nebis.ch/objects/pdf03/z01_010161011_01.pdf Titelblatt und Inhaltsverzeichnis VIEW pdf SWISSBIB 317151606 ORANGE 317151606