cad a22 4500 357735854 20181103044139.0 cr unu---uuuuu 160303s2016 xx s 000 0 eng 10.5167/uzh-123215 doi 10.1111/vaa.12348 doi (ZORA)oai:www.zora.uzh.ch:123215 570 ddc 630 ddc 26870925 pmid Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy [Elektronische Daten] [Karin S Kalchofner Guerrero, Ivo Campagna, Rodolfo Bruhl-Day, Cecilia Hegamin-Younger, Tomas G Guerrero] restrictedAccess eu-repo OBJECTIVE: Intraperitoneal (IP) bupivacaine provides postoperative analgesia in dogs undergoing ovariohysterectomy (OHE) alone or in combination with incisional (INC) bupivacaine. This study investigated whether the combination of INC and IP bupivacaine is superior to IP bupivacaine alone. STUDY DESIGN: Prospective, randomized, blinded clinical study. ANIMALS: Thirty-nine privately owned dogs undergoing OHE, aged 25 ± 23 months and weighing 11.8 ± 5.7 kg. METHODS: Dogs were premedicated with acepromazine (0.05 mg kg-1 ) and morphine (0.5 mg kg-1 ) intramuscularly (IM); anaesthesia was induced with propofol and maintained with isoflurane in oxygen. Carprofen (4 mg kg-1 ) was administered subcutaneously (SC) after intubation. Bupivacaine (3 mg kg-1 ) IP was administered before complete closure of the linea alba to all dogs. Dogs were randomly assigned into two groups: group B received bupivacaine (n = 20; 1 mg kg-1 ) and group S received saline (n = 19; 0.2 mL kg-1 ) INC as a subcutaneous 'splash' before skin closure. Postoperative analgesia was assessed with a dynamic interactive visual analogue scale, the short form of the Glasgow Composite Pain Scale, and mechanical nociceptive threshold (MNT) measurement at 0.5, 1, 2, 4, 6, 8, 12 and 20 hours after surgery by one blinded observer. Parametric data were tested using t-test; nonparametric data were analysed using the two-sample Wilcoxon test (p < 0.05). RESULTS: There was no significant difference between groups with regard to age, weight, surgical and anaesthetic duration, incision length, sedation and pain scores. MNT values decreased in both groups at all time points as compared with the baseline. No dog required rescue analgesia. No postoperative complications were observed. CONCLUSION AND CLINICAL RELEVANCE: Bupivacaine IP and carprofen SC after morphine IM did provide satisfactory postoperative analgesia in dogs undergoing OHE with the anaesthetic protocol used. There appears to be no clinical advantage to adding bupivacaine INC. Neither protocol could prevent the development of primary hyperalgesia. Equine Department zora Kalchofner Guerrero Karin S. joint author Campagna Ivo joint author Bruhl-Day Rodolfo joint author Hegamin-Younger Cecilia joint author Guerrero Tomas G. joint author Veterinary Anaesthesia and Analgesia 43(5):571-578 https://www.zora.uzh.ch/id/eprint/123215/1/Kalchofner%20et%20al%202016.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/123215/1/Kalchofner%20et%20al%202016.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Kalchofner Guerrero Karin S. joint author ZORA 700 1- Campagna Ivo joint author ZORA 700 1- Bruhl-Day Rodolfo joint author ZORA 700 1- Hegamin-Younger Cecilia joint author ZORA 700 1- Guerrero Tomas G. joint author ZORA 773 0- Veterinary Anaesthesia and Analgesia 43(5):571-578 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article restrictedAccess