cad a22 4500 357777832 20181103044139.0 cr unu---uuuuu 160304s2015 xx s 000 0 eng 10.5167/uzh-123218 doi 10.1515/acph-2015-0002 doi (ZORA)oai:www.zora.uzh.ch:123218 570 ddc 610 ddc Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases [Elektronische Daten] [Lulzime Ballazhi, Emil Popovski, Ahmed Jashari, Faik Imeri, Ibrahim Ibrahimi, Bozhana Mikhova, Kristina Mladenovska] openAccess eu-repo The study highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anticancer agents in metastatic breast cancer. Eight compounds, combining the coumarin core and five membered heterocycles (isoxazoles and thiazoles) in hydrazinyldiene- -chroman-2,4-diones, were characterized in terms of a potential antiproliferative effect on bone (SCP1833) and lung (SCP4175) metastatic breast cancer cell lines using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. Cell viability was evaluated after 48 and 72 h of treatment and the 50 % inhibitory concentrations were determined. The results demonstrated dose- and time-dependent activity, with the most potent molecules having a thiazole moiety, without or with additional methyl group(s) attached to the carbon(s) at position(s) 5 and/or 4 in the thiazole ring. These molecules possessed significantly higher potency against both test cell lines compared to 4-hydroxycoumarin Institute of Physiology zora Ballazhi Lulzime joint author Popovski Emil joint author Jashari Ahmed joint author Imeri Faik joint author Ibrahimi Ibrahim joint author Mikhova Bozhana joint author Mladenovska Kristina joint author Acta Pharmaceutica 65(1):53-63 https://www.zora.uzh.ch/id/eprint/123218/7/acph-2015-0002.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/123218/7/acph-2015-0002.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Ballazhi Lulzime joint author ZORA 700 1- Popovski Emil joint author ZORA 700 1- Jashari Ahmed joint author ZORA 700 1- Imeri Faik joint author ZORA 700 1- Ibrahimi Ibrahim joint author ZORA 700 1- Mikhova Bozhana joint author ZORA 700 1- Mladenovska Kristina joint author ZORA 773 0- Acta Pharmaceutica 65(1):53-63 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess