caa a22 4500 357790189 20171011071829.0 cr unu---uuuuu 160305e201501 xx s 000 0 eng 0305-1048 10.1093/nar/gku944 doi (BORIS)oai:boris.unibe.ch:76355 570 ddc 610 ddc 25300491 pmid TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei [Elektronische Daten] [Sanu Shameer, Flora J Logan-Klumpler, Florence Vinson, Ludovic Cottret, Benjamin Merlet, Fiona Achcar, Michael Boshart, Matthew Berriman, Rainer Breitling, Frédéric Bringaud, Peter Bütikofer, Amy M Cattanach, Bridget Bannerman-Chukualim, Darren J Creek, Kathryn Crouch, Harry P de Koning, Hubert Denise, Charles Ebikeme, Alan H Fairlamb, Michael A J Ferguson, Michael L Ginger, Christiane Hertz-Fowler, Eduard J Kerkhoven, Pascal Mäser, Paul A M Michels, Archana Nayak, David W Nes, Derek P Nolan, Christian Olsen, Fatima Silva-Franco, Terry K Smith, Martin C Taylor, Aloysius G M Tielens, Michael D Urbaniak, Jaap J van Hellemond, Isabel M Vincent, Shane R Wilkinson, Susan Wyllie, Fred R Opperdoes, Michael P Barrett, Fabien Jourdan] publishedVersion openAccess eu-repo The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome. Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments. Here we present a dynamic database, TrypanoCyc (http://www.metexplore.fr/trypanocyc/), which describes the generic and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible for human and animal African trypanosomiasis. In addition to enabling navigation through the BioCyc-based TrypanoCyc interface, we have also implemented a network-based representation of the information through MetExplore, yielding a novel environment in which to visualise the metabolism of this important parasite. Shameer Sanu joint author Logan-Klumpler Flora J. joint author Vinson Florence joint author Cottret Ludovic joint author Merlet Benjamin joint author Achcar Fiona joint author Boshart Michael joint author Berriman Matthew joint author Breitling Rainer joint author Bringaud Frédéric joint author Bütikofer Peter joint author Cattanach Amy M. joint author Bannerman-Chukualim Bridget joint author Creek Darren J. joint author Crouch Kathryn joint author de Koning Harry P. joint author Denise Hubert joint author Ebikeme Charles joint author Fairlamb Alan H. joint author Ferguson Michael A J. joint author Ginger Michael L. joint author Hertz-Fowler Christiane joint author Kerkhoven Eduard J. joint author Mäser Pascal joint author Michels Paul A M. joint author Nayak Archana joint author Nes David W. joint author Nolan Derek P. joint author Olsen Christian joint author Silva-Franco Fatima joint author Smith Terry K. joint author Taylor Martin C. joint author Tielens Aloysius G M. joint author Urbaniak Michael D. joint author van Hellemond Jaap J. joint author Vincent Isabel M. joint author Wilkinson Shane R. joint author Wyllie Susan joint author Opperdoes Fred R. joint author Barrett Michael P. joint author Jourdan Fabien joint author Nucleic acids research 43(DBissue), D637-D644 0305-1048 http://boris.unibe.ch/76355/1/B%C3%BCtikofer%20TrypanoCyc.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 http://boris.unibe.ch/76355/1/B%C3%BCtikofer%20TrypanoCyc.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Shameer Sanu joint author BORIS 700 1- Logan-Klumpler Flora J. joint author BORIS 700 1- Vinson Florence joint author BORIS 700 1- Cottret Ludovic joint author BORIS 700 1- Merlet Benjamin joint author BORIS 700 1- Achcar Fiona joint author BORIS 700 1- Boshart Michael joint author BORIS 700 1- Berriman Matthew joint author BORIS 700 1- Breitling Rainer joint author BORIS 700 1- Bringaud Frédéric joint author BORIS 700 1- Bütikofer Peter joint author BORIS 700 1- Cattanach Amy M. joint author BORIS 700 1- Bannerman-Chukualim Bridget joint author BORIS 700 1- Creek Darren J. joint author BORIS 700 1- Crouch Kathryn joint author BORIS 700 1- de Koning Harry P. joint author BORIS 700 1- Denise Hubert joint author BORIS 700 1- Ebikeme Charles joint author BORIS 700 1- Fairlamb Alan H. joint author BORIS 700 1- Ferguson Michael A J. joint author BORIS 700 1- Ginger Michael L. joint author BORIS 700 1- Hertz-Fowler Christiane joint author BORIS 700 1- Kerkhoven Eduard J. joint author BORIS 700 1- Mäser Pascal joint author BORIS 700 1- Michels Paul A M. joint author BORIS 700 1- Nayak Archana joint author BORIS 700 1- Nes David W. joint author BORIS 700 1- Nolan Derek P. joint author BORIS 700 1- Olsen Christian joint author BORIS 700 1- Silva-Franco Fatima joint author BORIS 700 1- Smith Terry K. joint author BORIS 700 1- Taylor Martin C. joint author BORIS 700 1- Tielens Aloysius G M. joint author BORIS 700 1- Urbaniak Michael D. joint author BORIS 700 1- van Hellemond Jaap J. joint author BORIS 700 1- Vincent Isabel M. joint author BORIS 700 1- Wilkinson Shane R. joint author BORIS 700 1- Wyllie Susan joint author BORIS 700 1- Opperdoes Fred R. joint author BORIS 700 1- Barrett Michael P. joint author BORIS 700 1- Jourdan Fabien joint author BORIS 773 0- Nucleic acids research 43(DBissue), D637-D644 0305-1048 SWISSBIB 357790189 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess