cad a22 4500 357808525 20200302065133.0 cr unu---uuuuu 160305e20151213xx s 000 0 eng 10.5167/uzh-122977 doi 10.1007/7651_2015_305 doi (ZORA)oai:www.zora.uzh.ch:122977 570 ddc 610 ddc 26659800 pmid Shakhova Olga In vitro derivation of melanocytes from embryonic neural crest stem cells [Elektronische Daten] [Olga Shakhova, Lukas Sommer] openAccess eu-repo During development, melanocyte progenitors originate from the neural crest, a transient embryonic structure in vertebrates that gives rise to a variety of cell types including neurons and glia of the peripheral nervous system, smooth muscle cells of the cardiovascular system, chondrocytes and osteoblasts of the craniofacial elements, and pigment cells in the skin. In this chapter, we describe a method for the differentiation of multipotent embryonic neural crest stem cells into differentiated pigmented melanocytes by using in vitro explant culture system. This protocol allows the dissection of genetic and cellular mechanisms regulating neural crest stem cell and melanocyte development. Based on this knowledge it is possible to make predictions about processes that might also be implicated in melanoma initiation and progression. Institute of Anatomy zora Clinic for Oncology and Hematology zora Sommer Lukas joint author Methods in Molecular Biology:1-8. https://www.zora.uzh.ch/id/eprint/122977/1/Methods%20in%20Molecular%20Biology_accepted%20manuscript.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/122977/1/Methods%20in%20Molecular%20Biology_accepted%20manuscript.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Shakhova Olga ZORA 700 1- Sommer Lukas joint author ZORA 773 0- Methods in Molecular Biology:1-8 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess