caa a22 4500 357880080 20170617031055.0 cr unu---uuuuu 160308s2015 xx s 000 0 eng 1664-3224 10.3389/fimmu.2015.00588 doi (BORIS)oai:boris.unibe.ch:77191 610 ddc 26635802 pmid Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death [Elektronische Daten] [Abhishek D Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R Hamblin, Akseli Hemminki, Martin Herrmann, James W Hodge, Oliver Kepp, Guido Kroemer, Dmitri V Krysko, Walter G Land, Frank Madeo, Angelo A Manfredi, Stephen R Mattarollo, Christian Maueroder, Nicolò Merendino, Gabriele Multhoff, Thomas Pabst, Jean-Ehrland Ricci, Chiara Riganti, Erminia Romano, Nicole Rufo, Mark J Smyth, Jürgen Sonnemann, Radek Spisek, John Stagg, Erika Vacchelli, Peter Vandenabeele, Lien Vandenberk, Benoit J Van den Eynde, Stefaan Van Gool, Francesca Velotti, Laurence Zitvogel, Patrizia Agostinis] publishedVersion openAccess eu-repo The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation. Garg Abhishek D. joint author Galluzzi Lorenzo joint author Apetoh Lionel joint author Baert Thais joint author Birge Raymond B. joint author Bravo-San Pedro José Manuel joint author Breckpot Karine joint author Brough David joint author Chaurio Ricardo joint author Cirone Mara joint author Coosemans An joint author Coulie Pierre G. joint author De Ruysscher Dirk joint author Dini Luciana joint author de Witte Peter joint author Dudek-Peric Aleksandra M. joint author Faggioni Alberto joint author Fucikova Jitka joint author Gaipl Udo S. joint author Golab Jakub joint author Gougeon Marie-Lise joint author Hamblin Michael R. joint author Hemminki Akseli joint author Herrmann Martin joint author Hodge James W. joint author Kepp Oliver joint author Kroemer Guido joint author Krysko Dmitri V. joint author Land Walter G. joint author Madeo Frank joint author Manfredi Angelo A. joint author Mattarollo Stephen R. joint author Maueroder Christian joint author Merendino Nicolò joint author Multhoff Gabriele joint author Pabst Thomas joint author Ricci Jean-Ehrland joint author Riganti Chiara joint author Romano Erminia joint author Rufo Nicole joint author Smyth Mark J. joint author Sonnemann Jürgen joint author Spisek Radek joint author Stagg John joint author Vacchelli Erika joint author Vandenabeele Peter joint author Vandenberk Lien joint author Van den Eynde Benoit J. joint author Van Gool Stefaan joint author Velotti Francesca joint author Zitvogel Laurence joint author Agostinis Patrizia joint author Frontiers in immunology 6(588), p. 588 1664-3224 http://boris.unibe.ch/77191/1/fimmu-06-00588.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 http://boris.unibe.ch/77191/1/fimmu-06-00588.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Garg Abhishek D. joint author BORIS 700 1- Galluzzi Lorenzo joint author BORIS 700 1- Apetoh Lionel joint author BORIS 700 1- Baert Thais joint author BORIS 700 1- Birge Raymond B. joint author BORIS 700 1- Bravo-San Pedro José Manuel joint author BORIS 700 1- Breckpot Karine joint author BORIS 700 1- Brough David joint author BORIS 700 1- Chaurio Ricardo joint author BORIS 700 1- Cirone Mara joint author BORIS 700 1- Coosemans An joint author BORIS 700 1- Coulie Pierre G. joint author BORIS 700 1- De Ruysscher Dirk joint author BORIS 700 1- Dini Luciana joint author BORIS 700 1- de Witte Peter joint author BORIS 700 1- Dudek-Peric Aleksandra M. joint author BORIS 700 1- Faggioni Alberto joint author BORIS 700 1- Fucikova Jitka joint author BORIS 700 1- Gaipl Udo S. joint author BORIS 700 1- Golab Jakub joint author BORIS 700 1- Gougeon Marie-Lise joint author BORIS 700 1- Hamblin Michael R. joint author BORIS 700 1- Hemminki Akseli joint author BORIS 700 1- Herrmann Martin joint author BORIS 700 1- Hodge James W. joint author BORIS 700 1- Kepp Oliver joint author BORIS 700 1- Kroemer Guido joint author BORIS 700 1- Krysko Dmitri V. joint author BORIS 700 1- Land Walter G. joint author BORIS 700 1- Madeo Frank joint author BORIS 700 1- Manfredi Angelo A. joint author BORIS 700 1- Mattarollo Stephen R. joint author BORIS 700 1- Maueroder Christian joint author BORIS 700 1- Merendino Nicolò joint author BORIS 700 1- Multhoff Gabriele joint author BORIS 700 1- Pabst Thomas joint author BORIS 700 1- Ricci Jean-Ehrland joint author BORIS 700 1- Riganti Chiara joint author BORIS 700 1- Romano Erminia joint author BORIS 700 1- Rufo Nicole joint author BORIS 700 1- Smyth Mark J. joint author BORIS 700 1- Sonnemann Jürgen joint author BORIS 700 1- Spisek Radek joint author BORIS 700 1- Stagg John joint author BORIS 700 1- Vacchelli Erika joint author BORIS 700 1- Vandenabeele Peter joint author BORIS 700 1- Vandenberk Lien joint author BORIS 700 1- Van den Eynde Benoit J. joint author BORIS 700 1- Van Gool Stefaan joint author BORIS 700 1- Velotti Francesca joint author BORIS 700 1- Zitvogel Laurence joint author BORIS 700 1- Agostinis Patrizia joint author BORIS 773 0- Frontiers in immunology 6(588), p. 588 1664-3224 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess