cad a22 4500 357896629 20181103044059.0 cr unu---uuuuu 160308e20160120xx s 000 0 eng 10.5167/uzh-120978 doi 10.1016/j.jvc.2015.10.008 doi (ZORA)oai:www.zora.uzh.ch:120978 570 ddc 630 ddc 26803196 pmid Intrapulmonary arteriovenous anastomoses in dogs with severe Angiostrongylus vasorum infection: clinical, radiographic, and echocardiographic evaluation [Elektronische Daten] [J Novo Matos, A Malbon, Matthias Dennler, Toni M Glaus] restrictedAccess eu-repo BACKGROUND: In both humans and dogs the pulmonary vasculature is able to recruit large-diameter anatomical intrapulmonary arteriovenous anastomoses (IPAVAs). In healthy people the opening of these anastomoses affects the degree of exercise-induced increase in pulmonary arterial pressure. The presence of these IPAVAs can be demonstrated using saline contrast echocardiography. OBJECTIVES: The aims of the present study were to characterize severely affected, naturally infected dogs with Angiostrongylusvasorum, to evaluate if these dogs can open IPAVAs, and to assess if the recruitment of such anastomoses affects the severity of pulmonary hypertension (PH). ANIMALS: Eight client-owned dogs with severe A. vasorum infection were recruited. METHODS: Dogs with A. vasorum infection that presented with severe dyspnea and/or syncope were prospectively screened by echocardiography for the presence of PH and IPAVAs. Only severely affected dogs, based on a combination of clinical, radiographic and echocardiographic abnormalities, were enrolled. RESULTS: Opening of IPAVAs could be demonstrated in three dogs with no to moderate PH, and could not be demonstrated in five dogs with severe PH. In two dogs thoracic radiographs showed only mild interstitial changes, while computer tomography and postmortem examination revealed severe pulmonary interstitial and vascular disease. CONCLUSIONS: These results suggest that dogs may open IPAVAs and that opening of such anastomoses may play a regulatory role in the development of PH. There may be a marked discrepancy between radiographic changes and disease severity in A.vasorum. Institute of Veterinary Pathology zora Department of Small Animals zora Novo Matos J. joint author Malbon A. joint author Dennler Matthias joint author Glaus Toni M. joint author Journal of Veterinary Cardiology 18(2):110-124 https://www.zora.uzh.ch/id/eprint/120978/1/Glaus_2016_Cardiology.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/120978/1/Glaus_2016_Cardiology.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Novo Matos J. joint author ZORA 700 1- Malbon A. joint author ZORA 700 1- Dennler Matthias joint author ZORA 700 1- Glaus Toni M. joint author ZORA 773 0- Journal of Veterinary Cardiology 18(2):110-124 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article restrictedAccess