cad a22 4500 357896718 20181103044140.0 cr unu---uuuuu 160308s2016 xx s 000 0 eng 10.5167/uzh-123262 doi 10.1002/ptr.5604 doi (ZORA)oai:www.zora.uzh.ch:123262 610 ddc Adverse effects of plant food supplements and plants consumed as food: Results from the poisons centres-based PlantLIBRA study [Elektronische Daten] [Saskia Lüde, Sarah Vecchio, Sandra Sinno-Tellier, Aymeric Dopter, Harriet Mustonen, Slavica Vucinic, Birgitta Jonsson, Dieter Müller, Ligia Veras Gimenez Fruchtengarten, Karl Hruby, Elizabeth De Souza Nascimento, Chiara Di Lorenzo, Patrizia Restani, Hugo Kupferschmidt, Alessandro Ceschi] openAccess eu-repo Plant food supplements (PFS) are products of increasing popularity and wide-spread distribution. Nevertheless, information about their risks is limited. To fill this gap, a poisons centres-based study was performed as part of the EU project PlantLIBRA. Multicentre retrospective review of data from selected European and Brazilian poisons centres, involving human cases of adverse effects due to plants consumed as food or as ingredients of food supplements recorded between 2006 and 2010. Ten poisons centres provided a total of 75 cases. In 57 cases (76%) a PFS was involved; in 18 (24%) a plant was ingested as food. The 10 most frequently reported plants were Valeriana officinalis, Camellia sinensis, Paullinia cupana, Melissa officinalis, Passiflora incarnata, Mentha piperita, Glycyrrhiza glabra, Ilex paraguariensis, Panax ginseng, and Citrus aurantium. The most frequently observed clinical effects were neurotoxicity and gastro-intestinal symptoms. Most cases showed a benign clinical course; however, five cases were severe. PFS-related adverse effects seem to be relatively infrequent issues for poisons centres. Most cases showed mild symptoms. Nevertheless, the occurrence of some severe adverse effects and the increasing popularity of PFS require continuous active surveillance, and further research is warranted. Clinic for Clinical Pharmacology and Toxicology zora Pharmacology zora Lüde Saskia joint author Vecchio Sarah joint author Sinno-Tellier Sandra joint author Dopter Aymeric joint author Mustonen Harriet joint author Vucinic Slavica joint author Jonsson Birgitta joint author Müller Dieter joint author Veras Gimenez Fruchtengarten Ligia joint author Hruby Karl joint author De Souza Nascimento Elizabeth joint author Di Lorenzo Chiara joint author Restani Patrizia joint author Kupferschmidt Hugo joint author Ceschi Alessandro joint author Phytotherapy Research 30(6):988-996 https://www.zora.uzh.ch/id/eprint/123262/1/Revision2_PTR-15-1296_PlantLibra%20Adverse%20effects%20PFS_ZORA.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora EC/FP7/245199 zora grantAgreement ZORA 856 40 https://www.zora.uzh.ch/id/eprint/123262/1/Revision2_PTR-15-1296_PlantLibra%20Adverse%20effects%20PFS_ZORA.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Lüde Saskia joint author ZORA 700 1- Vecchio Sarah joint author ZORA 700 1- Sinno-Tellier Sandra joint author ZORA 700 1- Dopter Aymeric joint author ZORA 700 1- Mustonen Harriet joint author ZORA 700 1- Vucinic Slavica joint author ZORA 700 1- Jonsson Birgitta joint author ZORA 700 1- Müller Dieter joint author ZORA 700 1- Veras Gimenez Fruchtengarten Ligia joint author ZORA 700 1- Hruby Karl joint author ZORA 700 1- De Souza Nascimento Elizabeth joint author ZORA 700 1- Di Lorenzo Chiara joint author ZORA 700 1- Restani Patrizia joint author ZORA 700 1- Kupferschmidt Hugo joint author ZORA 700 1- Ceschi Alessandro joint author ZORA 773 0- Phytotherapy Research 30(6):988-996 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess