cad a22 4500 357963784 20181103044141.0 cr unu---uuuuu 160310s2016 xx s 000 0 eng 10.5167/uzh-123307 doi 10.1159/000443420 doi (ZORA)oai:www.zora.uzh.ch:123307 570 ddc 610 ddc 630 ddc 26981631 pmid High resolution ultrasonography for assessment of renal cysts in the PCK rat model of autosomal recessive polycystic kidney disease [Elektronische Daten] [Sarika Kapoor, Daniel Rodriguez, Katharyn J Mitchell, Rudolf P Wüthrich] openAccess eu-repo BACKGROUND/AIMS: The PCK rat model of polycystic kidney disease is characterized by the progressive development of renal medullary cysts. Here, we evaluated the suitability of high resolution ultrasonography (HRU) to assess the kidney and cyst volume in PCK rats, testing three different ultrasound image analysis methods, and correlating them with kidneys weights and histological examinations. METHODS: After inducing anesthesia, PCK rats (n=18) were subjected to HRU to visualize the kidneys, to perform numeric and volumetric measurements of the kidney and any cysts observed, and to generate 3-dimensional images of the cysts within the kidney parenchyma. RESULTS: HRU provided superior information in comparison to microscopic analysis of stained kidney sections. HRU-based kidney volumes correlated strongly with kidney weights (R2=0.809; P<0.0001). CONCLUSION: HRU represents a useful diagnostic tool for kidney and cyst volume measurements in PCK rats. Sequential HRU examinations may be useful to study the effect of drugs on cyst growth without the need to euthanize experimental animals. Clinic for Nephrology zora Equine Department zora Kapoor Sarika joint author Rodriguez Daniel joint author Mitchell Katharyn J. joint author Wüthrich Rudolf P. joint author Kidney & Blood Pressure Research 41(2):186-196 https://www.zora.uzh.ch/id/eprint/123307/1/Kapoor%202016%20%28Kidney%20and%20Blood%20pressure%20research%29%20HRU%20kidney%20cysts_final.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/123307/1/Kapoor%202016%20%28Kidney%20and%20Blood%20pressure%20research%29%20HRU%20kidney%20cysts_final.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Kapoor Sarika joint author ZORA 700 1- Rodriguez Daniel joint author ZORA 700 1- Mitchell Katharyn J. joint author ZORA 700 1- Wüthrich Rudolf P. joint author ZORA 773 0- Kidney & Blood Pressure Research 41(2):186-196 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess