caa a22 4500 378849425 CHVBK 20180305123319.0 cr unu---uuuuu 161128e20030919xx s 000 0 eng 10.1515/CCLM.2003.203 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.203 Reference Levels of Insulin-Like Growth Factor I in the Serum of Healthy Adults: Comparison of Four Immunoassays [Elektronische Daten] [Michael Bernd Ranke, Karl Josef Osterziel, Roland Schweizer, Burkhardt Schuett, Karin Weber, Patricia Röbbel, Arnold Vornwald, Gunnar Blumenstock, Martin W. Elmlinger] The measurement of insulin-like growth factor-I (IGF-I) has become an essential tool for diagnosing growth hormone deficiency and acromegaly, as well as for monitoring the efficacy of treatment in these disorders. The latter aspect gains significance in the light of epidemiological studies which indicate a relationship between IGF-I levels and the incidence of certain malignancies. We aimed to evaluate the performance of widely implemented IGF-I assays by testing four representative, commercially available immunoassays. Thus, four parallel determinations of the IGF-I levels of 427 healthy blood donors aged between 18 and 79 years were conducted. Apart from divergent performance criteria, the assays also differed systematically. These differences were, however, linear and of lower magnitude among the lower ranges. We conclude that despite the wide variance among commercially available IGF-I assays, which principally involve assayspecific normative data, each of the implemented assays was robust and thus an appropriate tool in the diagnostic workup of growth hormone deficiency in adult life, when IGF-I levels are low. Clin Chem Lab Med 2003; 41(10):13291334 Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Ranke Michael Bernd aut Osterziel Karl Josef aut Schweizer Roland aut Schuett Burkhardt aut Weber Karin aut Röbbel Patricia aut Vornwald Arnold aut Blumenstock Gunnar aut Elmlinger Martin W. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1329-1334 1434-6621 41:10<1329 2003 41 cclm https://doi.org/10.1515/CCLM.2003.203 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.203 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ranke Michael Bernd aut NATIONALLICENCE 700 1- Osterziel Karl Josef aut NATIONALLICENCE 700 1- Schweizer Roland aut NATIONALLICENCE 700 1- Schuett Burkhardt aut NATIONALLICENCE 700 1- Weber Karin aut NATIONALLICENCE 700 1- Röbbel Patricia aut NATIONALLICENCE 700 1- Vornwald Arnold aut NATIONALLICENCE 700 1- Blumenstock Gunnar aut NATIONALLICENCE 700 1- Elmlinger Martin W. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1329-1334 1434-6621 41:10<1329 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter