caa a22 4500 378849433 CHVBK 20180305123319.0 cr unu---uuuuu 161128e20030919xx s 000 0 eng 10.1515/CCLM.2003.195 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.195 Mitochondrial Oxidative Stress and Mitochondrial DNA [Elektronische Daten] [Dongchon Kang, Naotaka Hamasaki] Mitochondria produce reactive oxygen species (ROS) under physiological conditions in association with activity of the respiratory chain in aerobic ATP production. The production of ROS is essentially a function of O2 consumption. Hence, increased mitochondrial activity per se can be an oxidative stress to cells. Furthermore, production of ROS is markedly enhanced in many pathological conditions in which the respiratory chain is impaired. Because mitochondrial DNA, which is essential for execution of normal oxidative phosphorylation, is located in proximity to the ROS-generating respiratory chain, it is more oxidatively damaged than is nuclear DNA. Cumulative damage of mitochondrial DNA is implicated in the aging process and in the progression of such common diseases as diabetes, cancer, and heart failure. Clin Chem Lab Med 2003; 41(10):12811288 Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Kang Dongchon aut Hamasaki Naotaka aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1281-1288 1434-6621 41:10<1281 2003 41 cclm https://doi.org/10.1515/CCLM.2003.195 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.195 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Dongchon aut NATIONALLICENCE 700 1- Hamasaki Naotaka aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1281-1288 1434-6621 41:10<1281 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter