caa a22 4500 378849468 CHVBK 20180305123320.0 cr unu---uuuuu 161128e20030919xx s 000 0 eng 10.1515/CCLM.2003.199 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.199 Effects of Acute, Heavy-Resistance Exercise on Urinary Peptide Hormone Excretion in Humans [Elektronische Daten] [Elio F. De Palo, Rosalba Gatti, Federica Lancerin, Carlo B. De Palo, Enrico Cappellin, Giuseppe Soldà, Paolo Spinella] To examine physical exercise-related changes in urinary excretion of protein/peptide hormones and to correlate modifications with the general increase in post-exercise proteinuria, urine C-peptide, insulin and insulin-like growth factor-I (IGF-I) and their plasma concentrations were measured. Plasma and urinary C-peptide, insulin and IGF-I before (Bex) and at the end (Eex) of physical exercise (a 2.5-hour competition, 102 km) were analysed in 20 young cyclists. At Eex compared with Bex, concentration of urinary C-peptide decreased slightly but significantly (21.3±2.7 vs. 13.5±1.7 nmol/l), but urinary insulin and urinary IGF-I concentrations significantly increased at Eex (92.5±4.2 vs. 131.4±15.7 pmol/l and 10.0±2.1 vs. 33.6±3.8 pmol/l, respectively). Plasma insulin and plasma C-peptide significantly decreased, whereas plasma IGF-I was unchanged. Urinary concentrations of total proteins and creatinine significantly increased. Both Eex urinary C-peptide/urinary protein and urinary C-peptide/urinary creatinine ratios were significantly reduced. The correlation between C-peptide and insulin in plasma was confirmed at Bex as well as Eex, but in urine only at Bex. An increased renal tubular reabsorption of C-peptide at the end of exercise might be suggested, but the expected values considering creatinine excretion were almost three times less. The Eex urinary insulin concentration was higher than expected, considering the circulation levels, but lower when compared with the expected concentration considering creatinine excretion. Physical exercise proteinuria, related to an increased protein filtration and a saturation of the mechanisms responsible for the reabsorption, does not appear similar for all peptide hormones. Clin Chem Lab Med 2003; 41(10):13081313 Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Palo Elio F. De aut Gatti Rosalba aut Lancerin Federica aut Palo Carlo B. De aut Cappellin Enrico aut Soldà Giuseppe aut Spinella Paolo aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1308-1313 1434-6621 41:10<1308 2003 41 cclm https://doi.org/10.1515/CCLM.2003.199 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.199 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Palo Elio F. De aut NATIONALLICENCE 700 1- Gatti Rosalba aut NATIONALLICENCE 700 1- Lancerin Federica aut NATIONALLICENCE 700 1- Palo Carlo B. De aut NATIONALLICENCE 700 1- Cappellin Enrico aut NATIONALLICENCE 700 1- Soldà Giuseppe aut NATIONALLICENCE 700 1- Spinella Paolo aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1308-1313 1434-6621 41:10<1308 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter