caa a22 4500 378849476 CHVBK 20180305123320.0 cr unu---uuuuu 161128e20030919xx s 000 0 eng 10.1515/CCLM.2003.200 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.200 HMG-CoA Reductase Inhibitors Are Associated with Decreased Serum Neopterin Levels in Stable Coronary Artery Disease [Elektronische Daten] [Roland B. Walter, Dietmar Fuchs, Günter Weiss, Thomas R. Walter, Walter H. Reinhart] Neopterin, a marker of stimulated cellular immune response, is increased in unstable angina, acute myocardial infarction and possibly stable coronary artery disease. 3-Hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors (statins) have antiinflammatory properties, but their effect on neopterin largely unknown. Neopterin was measured in 232 patients undergoing elective coronary angiography and compared to the degree of atherosclerosis, use of concomitant medications and demographics. Neopterin was lower in subjects using statins (n = 66) compared to those not taking statins (median (range): 6.65 (4.1-18.3) vs. 7.70 (3.6-29.1) nmol/l, p < 0.0001). This association was also found in the subgroup of patients with coronary artery disease (1-3-vessel disease, n = 164; 6.60 (4.1-18.3) vs. 7.80 (3.6-29.1) nmol/l, p = 0.0012), whereas only a slight tendency toward lower neopterin levels was found in the group without atherosclerosis (6.90 (5.1-16.0) vs. 7.60 (4.0-18.5) nmol/l, p = 0.17). In patients with coronary atherosclerosis, neopterin concentrations were lower in smokers (n = 105) compared to nonsmokers (7.20 (3.6-29.1) vs. 7.90 (4.4-18.6) nmol/l, p < 0.02), confirming previous observations. However, use of statins was associated with lower neopterin levels in both nonsmokers and smokers (6.70 (4.1-18.3) vs. 7.60 (3.6-29.1) nmol/l, p < 0.05, and 6.20 (5.2-16.0) vs. 7.80 (4.4-18.6) nmol/l, p < 0.05, respectively). Overall, similar serum neopterin concentrations were found in patients with coronary atherosclerosis and those without. In accordance with their antiinflammatory effects, the use of statins is associated with lower neopterin levels in patients undergoing elective coronary angiography. Clin Chem Lab Med 2003; 41(10):13141319 Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Walter Roland B. aut Fuchs Dietmar aut Weiss Günter aut Walter Thomas R. aut Reinhart Walter H. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1314-1319 1434-6621 41:10<1314 2003 41 cclm https://doi.org/10.1515/CCLM.2003.200 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.200 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walter Roland B. aut NATIONALLICENCE 700 1- Fuchs Dietmar aut NATIONALLICENCE 700 1- Weiss Günter aut NATIONALLICENCE 700 1- Walter Thomas R. aut NATIONALLICENCE 700 1- Reinhart Walter H. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1314-1319 1434-6621 41:10<1314 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter