Common Variants in the Lipoprotein Lipase Gene in Brazil: Association with Lipids and Angiographically Assessed Coronary Atherosclerosis
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.207 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.207 | ||
| 245 | 0 | 0 | |a Common Variants in the Lipoprotein Lipase Gene in Brazil: Association with Lipids and Angiographically Assessed Coronary Atherosclerosis |h [Elektronische Daten] |c [Domingos L. S. Rios, André F. Vargas, Gisele M. Ewald, Marco R. Torres, Alcides J. Zago, Sídia M. Callegari-Jacques, Mara H. Hutz] |
| 520 | 3 | |a Lipoprotein lipase is the rate-limiting enzyme in the lipolysis of plasma triglyceride-rich lipoproteins. We studied six variants (T-93G, D9N, N291S, PvuII, HindIII and S447X) in the lipoprotein lipase (LPL) gene in 309 nondiabetic patients with angiographically assessed coronary artery disease and in 197 controls in a southern Brazilian population of European descent. The HindIII H-allele was associated with lower triglycerides (p < 0.01) and higher high-density lipoprotein cholesterol (p = 0.03) levels, and the S447X mutation was associated with lower triglyceride levels (p < 0.01) in males, but not females. No other significant lipid associations were observed. Haplotypes were derived from these two sites (HindIII/S447X), and carriers of H-S and H-X haplotypes showed lower triglycerides (p < 0.01) and increased highdensity lipoprotein cholesterol (p = 0.01) levels when compared to the H+S haplotype in males. In this gender, the H-X haplotype was associated with a protective effect (OR = 0.36, 95%CI = 0.13-0.97) for significant disease (≥60% of luminal coronary stenosis), even controlling for other classical risk factors. Clin Chem Lab Med 2003; 41(10):13511356 | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Rios |D Domingos L. S. |4 aut | |
| 700 | 1 | |a Vargas |D André F. |4 aut | |
| 700 | 1 | |a Ewald |D Gisele M. |4 aut | |
| 700 | 1 | |a Torres |D Marco R. |4 aut | |
| 700 | 1 | |a Zago |D Alcides J. |4 aut | |
| 700 | 1 | |a Callegari-Jacques |D Sídia M. |4 aut | |
| 700 | 1 | |a Hutz |D Mara H. |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/10(2003-09-19), 1351-1356 |x 1434-6621 |q 41:10<1351 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.207 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.207 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rios |D Domingos L. S. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vargas |D André F. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ewald |D Gisele M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Torres |D Marco R. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zago |D Alcides J. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Callegari-Jacques |D Sídia M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hutz |D Mara H. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/10(2003-09-19), 1351-1356 |x 1434-6621 |q 41:10<1351 |1 2003 |2 41 |o cclm | ||
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