caa a22 4500 378849514 CHVBK 20180305123320.0 cr unu---uuuuu 161128e20030919xx s 000 0 eng 10.1515/CCLM.2003.207 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.207 Common Variants in the Lipoprotein Lipase Gene in Brazil: Association with Lipids and Angiographically Assessed Coronary Atherosclerosis [Elektronische Daten] [Domingos L. S. Rios, André F. Vargas, Gisele M. Ewald, Marco R. Torres, Alcides J. Zago, Sídia M. Callegari-Jacques, Mara H. Hutz] Lipoprotein lipase is the rate-limiting enzyme in the lipolysis of plasma triglyceride-rich lipoproteins. We studied six variants (T-93G, D9N, N291S, PvuII, HindIII and S447X) in the lipoprotein lipase (LPL) gene in 309 nondiabetic patients with angiographically assessed coronary artery disease and in 197 controls in a southern Brazilian population of European descent. The HindIII H-allele was associated with lower triglycerides (p < 0.01) and higher high-density lipoprotein cholesterol (p = 0.03) levels, and the S447X mutation was associated with lower triglyceride levels (p < 0.01) in males, but not females. No other significant lipid associations were observed. Haplotypes were derived from these two sites (HindIII/S447X), and carriers of H-S and H-X haplotypes showed lower triglycerides (p < 0.01) and increased highdensity lipoprotein cholesterol (p = 0.01) levels when compared to the H+S haplotype in males. In this gender, the H-X haplotype was associated with a protective effect (OR = 0.36, 95%CI = 0.13-0.97) for significant disease (≥60% of luminal coronary stenosis), even controlling for other classical risk factors. Clin Chem Lab Med 2003; 41(10):13511356 Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Rios Domingos L. S. aut Vargas André F. aut Ewald Gisele M. aut Torres Marco R. aut Zago Alcides J. aut Callegari-Jacques Sídia M. aut Hutz Mara H. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1351-1356 1434-6621 41:10<1351 2003 41 cclm https://doi.org/10.1515/CCLM.2003.207 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.207 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rios Domingos L. S. aut NATIONALLICENCE 700 1- Vargas André F. aut NATIONALLICENCE 700 1- Ewald Gisele M. aut NATIONALLICENCE 700 1- Torres Marco R. aut NATIONALLICENCE 700 1- Zago Alcides J. aut NATIONALLICENCE 700 1- Callegari-Jacques Sídia M. aut NATIONALLICENCE 700 1- Hutz Mara H. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/10(2003-09-19), 1351-1356 1434-6621 41:10<1351 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter