MSP-1 Malaria Pseudopeptide Analogs:Biological and Immunological Significance andThree-Dimensional Structure
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| 024 | 7 | 0 | |a 10.1515/BC.2003.008 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2003.008 | ||
| 245 | 0 | 0 | |a MSP-1 Malaria Pseudopeptide Analogs:Biological and Immunological Significance andThree-Dimensional Structure |h [Elektronische Daten] |c [J.M. Lozano, M.P. Alba, M. Vanegas, Y. Silva, J.L. Torres-Castellanos, M.E. Patarroyo] |
| 520 | 3 | |a Merozoite Surface Protein-1 (MSP-1) has been considered as a malaria vaccine candidate. It is processed during the Plasmodium falciparum invasion process of red blood cells (RBCs). A conserved MSP-1 C-terminal peptide was identified as a high-activity erythrocyte binding peptide (HAEBP) termed 1585. Since conserved HAEBPs are neither antigenic nor immunogenic we decided to assess the significance of a single peptide bond replacement in 1585. Thus, two pseudopeptides were obtained by introducing a ψ[CH2-NH] reduced amide isoster into the 1585 critical binding motif. The pseudopeptides bound to different HLA-DR alleles, suggesting that backbone modifications affect MHC-II binding patterns. Pseudopeptide antibodies inhibit in vitro parasite RBC invasion by recognizing MSP-1. Each pseudopeptide-induced antibody shows distinct recognition patterns. 1H-NMR studies demonstrated that isoster bonds modulate the pseudopeptides structure and thus their immunological properties, therefore representing a possible subunit malaria vaccine component. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 700 | 1 | |a Lozano |D J.M. |4 aut | |
| 700 | 1 | |a Alba |D M.P. |4 aut | |
| 700 | 1 | |a Vanegas |D M. |4 aut | |
| 700 | 1 | |a Silva |D Y. |4 aut | |
| 700 | 1 | |a Torres-Castellanos |D J.L. |4 aut | |
| 700 | 1 | |a Patarroyo |D M.E. |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 384/1(2003-01-27), 71-82 |x 1431-6730 |q 384:1<71 |1 2003 |2 384 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2003.008 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2003.008 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lozano |D J.M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alba |D M.P. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vanegas |D M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Silva |D Y. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Torres-Castellanos |D J.L. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Patarroyo |D M.E. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 384/1(2003-01-27), 71-82 |x 1431-6730 |q 384:1<71 |1 2003 |2 384 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
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