caa a22 4500 378851012 CHVBK 20180305123323.0 cr unu---uuuuu 161128e20031120xx s 000 0 eng 10.1515/JPM.2003.079 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2003.079 Umbilical glutathione levels are higher after vaginal birth than after cesarean section [Elektronische Daten] [M. T. M. Raijmakers, E. M. Roes, E. A. P. Steegers, B. van der Wildt, W. H. M. Peters] Glutathione plays an important role in quenching reactive oxygen species, resulting in oxidation of glutathione, which in times of prolonged oxidative stress may be excreted from the erythrocyte. We investigated arterial and venous umbilical cord levels of glutathione in neonates born by vaginal delivery (n = 140) or cesarean section (n = 38). In a subset of neonates who were delivered vaginally maternal levels were assessed in parallel (n = 14). Median (5th-95th percentile) glutathione levels in venous and arterial umbilical samples were higher after vaginal delivery as compared to cesarean section, 2.7 (0.9-7.3) versus 2.0 (0.6-11.5; P < 0.03) and 3.5 (0.6-22.7) versus 2.3 (0.7-24.3) μmol/L (P < 0.02), respectively. Maternal glutathione levels were higher, 7.8 (4.3-10.6) μmol/L, than corresponding venous (P < 0.001) or arterial (P < 0.02) umbilical levels. These results suggest that vaginal delivery is associated with more oxidative stress than delivery by cesarean section. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Raijmakers M. T. M. aut Roes E. M. aut Steegers E. A. P. aut van der Wildt B. aut Peters W. H. M. aut Journal of Perinatal Medicine Walter de Gruyter 31/6(2003-11-20), 520-522 0300-5577 31:6<520 2003 31 jpme https://doi.org/10.1515/JPM.2003.079 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2003.079 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raijmakers M. T. M. aut NATIONALLICENCE 700 1- Roes E. M. aut NATIONALLICENCE 700 1- Steegers E. A. P. aut NATIONALLICENCE 700 1- van der Wildt B. aut NATIONALLICENCE 700 1- Peters W. H. M. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 31/6(2003-11-20), 520-522 0300-5577 31:6<520 2003 31 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter