caa a22 4500 378851071 CHVBK 20180305123323.0 cr unu---uuuuu 161128e20031120xx s 000 0 eng 10.1515/JPM.2003.073 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2003.073 Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes [Elektronische Daten] [R. G. King, D. T. D. Osmond, S. P. Brennecke, N. M. Gude] The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies. Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. Hay WW: Regulation of placental metabolism by glucose supply. Reprod Fertil Dev 7 (1995) 365 C-D-glucose and Combs CA,E Gunderson, JL Kitzmiller, LA Gavin, EK Main: Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy. Diabetes Care 15 (1992) 1251 H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates. Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group. In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence King R. G. aut Osmond D. T. D. aut Brennecke S. P. aut Gude N. M. aut Journal of Perinatal Medicine Walter de Gruyter 31/6(2003-11-20), 475-483 0300-5577 31:6<475 2003 31 jpme https://doi.org/10.1515/JPM.2003.073 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2003.073 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- King R. G. aut NATIONALLICENCE 700 1- Osmond D. T. D. aut NATIONALLICENCE 700 1- Brennecke S. P. aut NATIONALLICENCE 700 1- Gude N. M. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 31/6(2003-11-20), 475-483 0300-5577 31:6<475 2003 31 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter