caa a22 4500 378852205 CHVBK 20180305123326.0 cr unu---uuuuu 161128e20031117xx s 000 0 eng 10.1515/CCLM.2003.233 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.233 Homocysteine Increases during Endurance Exercise [Elektronische Daten] [Markus Herrmann, Heike Schorr, Rima Obeid, Jürgen Scharhag, Axel Urhausen, Wilfried Kindermann, Wolfgang Herrmann] Hyperhomocysteinemia is a risk factor for cardiovascular and other diseases. Recently many endogenous and exogenous modulators of homocysteine (Hcy) have become known, e.g., B-vitamins. However, little is known about the effect of exercise on Hcy. The purpose of this study was to investigate the effect of three different types of acute endurance exercise on serum Hcy. We measured Hcy in 100 recreational athletes (87 males, 13 females) who participated in a marathon race (n = 46), a 100 km run (100 km; n = 12) or a 120 km mountain bike race (n = 42). Blood samples were taken before, 15 min and 3 h after the race. In athletes with pre-race Hcy >12 μmol/l we also determined folate and vitamin B12. Marathon running induced a Hcy increase of 64%, while mountain biking and 100 km running had no significant effect on Hcy. Pre-race Hcy (25th-75th percentile) overall; marathon race; 100 km; mountain bike race was 9.7 (7.1-11.5) μmol/l; 9.8 (7.4-11.1) μmol/l; 10.2 (6.6-13.2) μmol/l; 9.1 (6.9-13.5) μmol/l, respectively. At 15 min and 3 h post-race, Hcy was 11.9 (8.4-16.4) μmol/l; 16.1 (12.7-20.4) μmol/l; 9.5 (7.8-15.9) μmol/l; 8.8 (7.1-11.2) μmol/l, respectively, and 11.5 (8.9-15.7) μmol/l; 14.9 (11.5-20.0) μmol/l; 10.0 (8.1-11.8) μmol/l; 9.4 (7.4-12.1) μmol/l, respectively. The change in Hcy correlated negatively with the running time. Twenty-three athletes had pre-race Hcy levels >12 μmol/l, which were associated with relatively low folate (14.3 (11.6-18.9) nmol/l) and vitamin B12 levels (231 (183-261) pmol/l). Endurance exercise may induce a considerable Hcy increase, which varies between different disciplines and is most probably determined by the duration Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Herrmann Markus aut Schorr Heike aut Obeid Rima aut Scharhag Jürgen aut Urhausen Axel aut Kindermann Wilfried aut Herrmann Wolfgang aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1518-1524 1434-6621 41:11<1518 2003 41 cclm https://doi.org/10.1515/CCLM.2003.233 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herrmann Markus aut NATIONALLICENCE 700 1- Schorr Heike aut NATIONALLICENCE 700 1- Obeid Rima aut NATIONALLICENCE 700 1- Scharhag Jürgen aut NATIONALLICENCE 700 1- Urhausen Axel aut NATIONALLICENCE 700 1- Kindermann Wilfried aut NATIONALLICENCE 700 1- Herrmann Wolfgang aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1518-1524 1434-6621 41:11<1518 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter