caa a22 4500 378852248 CHVBK 20180305123326.0 cr unu---uuuuu 161128e20031117xx s 000 0 eng 10.1515/CCLM.2003.216 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.216 Does Homocysteine Cause Hypertension? [Elektronische Daten] [Coen D. A. Stehouwer, Coen van Guldener] Several studies, some population-based, have plasma homocysteine levels linked to blood pressure, especially systolic pressure. In one large and carefully conducted epidemiological study, each 5 μmol/l increase in plasma homocysteine was associated with an increase in systolic and diastolic blood pressure of 0.7/0.5 mmHg in men and 1.2/0.7 mmHg in women, which was independent of renal function and B vitamin status. In addition, observations that homocysteine-lowering therapies with folic acid-based treatments have been followed by decreases in blood pressure raise the possibility that the link between homocysteine and blood pressure is causal, which is important since homocysteine levels can easily be lowered by folic acid-based regimens. Mechanisms that could explain the relationship between homocysteine and blood pressure include homocysteine-induced arteriolar constriction, renal dysfunction and increased sodium reabsorption, and increased arterial stiffness. However, there is only circumstantial evidence that these mechanisms are operative in humans. In addition, confounding by subtle renal dysfunction or by unmeasured dietary and lifestyle factors cannot be excluded as an explanation for the association between homocysteine and blood pressure. At present, therefore, the hypothesis that homocysteine increases blood pressure must be considered unproven. Ongoing large intervention studies with homocysteine-lowering vitamins may show whether blood pressure is indeed lowered by these vitamins, whether the blood pressure decrease, if any, is explained by the decrease in homocysteine levels, and whether a vitamin treatment-associated decrease in cardiovascular morbidity, if any, is explained by the decrease in blood pressure. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Stehouwer Coen D. A. aut Guldener Coen van aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1408-1411 1434-6621 41:11<1408 2003 41 cclm https://doi.org/10.1515/CCLM.2003.216 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.216 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stehouwer Coen D. A. aut NATIONALLICENCE 700 1- Guldener Coen van aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1408-1411 1434-6621 41:11<1408 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter