Hyperhomocysteinaemia as a Risk Factor for Venous Thrombosis: An Update of the Current Evidence
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.215 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.215 | ||
| 100 | 1 | |a Heijer |D Martin den | |
| 245 | 1 | 0 | |a Hyperhomocysteinaemia as a Risk Factor for Venous Thrombosis: An Update of the Current Evidence |h [Elektronische Daten] |c [Martin den Heijer] |
| 520 | 3 | |a Classical homocystinuria is associated with arterial vascular diseases and venous thrombosis. In the last decade, many studies, including some prospective studies, have been published indicating that moderate hyperhomocysteinaemia is also a risk factor for venous thrombosis. The 677C>T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is an important cause of mild hyperhomocysteinaemia. Recent meta-analyses show an elevated risk of venous thrombosis for subjects with the TT-genotype. Based on the concept of ‘Mendelian randomisation', this observation supports the hypothesis that hyperhomocysteinaemia is a causal risk factor for venous thrombosis. The results of one homocysteine-lowering trial regarding venous thrombosis are awaited at the end of 2003. In this paper the current evidence for hyperhomocysteinaemia as a risk factor for venous thrombosis is being discussed. | |
| 540 | |a Copyright (c) 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/11(2003-11-17), 1404-1407 |x 1434-6621 |q 41:11<1404 |1 2003 |2 41 |o cclm | |
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| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Heijer |D Martin den | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/11(2003-11-17), 1404-1407 |x 1434-6621 |q 41:11<1404 |1 2003 |2 41 |o cclm | ||
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