caa a22 4500 378852353 CHVBK 20180305123326.0 cr unu---uuuuu 161128e20031117xx s 000 0 eng 10.1515/CCLM.2003.234 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.234 Comparison of the Influence of Volume-Oriented Training and High-Intensity Interval Training on Serum Homocysteine and Its Cofactors in Young, Healthy Swimmers [Elektronische Daten] [Markus Herrmann, John Wilkinson, Heike Schorr, Rima Obeid, Thomas Georg, Axel Urhausen, Jürgen Scharhag, Wilfried Kindermann, Wolfgang Herrmann] Background: Since homocysteine (Hcy) is a risk factor for cardiovascular and other diseases, it is important to know how exercise can modify it. Previous studies have suggested that endurance training influences Hcy. However, little is known about the effect of training intensity on Hcy. Materials and Methods: We investigated Hcy, vitamin B12, vitamin B6, folate and methylmalonic acid (MMA) before and after 3 weeks of volume-oriented training (VOL) (30 km/week) and high-intensity interval training (HIT) (20 km/week) in 20 young swimmers (16±2 years). Afterward, the athletes completed 5 days of recovery training. Results: The training induced a Hcy increase in HIT and VOL (6.47±0.95 μmol/l vs. 7.44±1.17 μmol/l and 7.33± 1.92 μmol/l vs. 8.28±1.42 μmol/l, respectively) that persisted during the recovery period (8.02±1.69 μmol/and 8.00±1.81 μmol/l, respectively). Vitamin B12 was unchanged after the training (539±166 ng/l vs. 556±192 ng/l and 480±144 ng/l vs. 491±124 ng/l, respectively) but decreased during the recovery period (459±134 ng/l and 451±116 ng/l, respectively). Folate showed an increase during the training (9.07±2.01 μg/vs. 11.71±4.08 μg/l and 10.34±2.32 μg/l vs. 11.13± 4.64 μg/l, respectively), which was reversible by the end of the recovery training (8.57±1.98 μg/l and 9.60±2.38 μg/l, respectively). Vitamin B6 and MMA did not change. For none of the measured parameters were there significant differences between HIT and VOL. Conclusion: Three weeks of strenuous swimming caused a prolonged Hcy increase, which was accompanied by changes in vitamin B12 and folate. The magnitude of these effects was not influenced by the training intensity. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Herrmann Markus aut Wilkinson John aut Schorr Heike aut Obeid Rima aut Georg Thomas aut Urhausen Axel aut Scharhag Jürgen aut Kindermann Wilfried aut Herrmann Wolfgang aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1525-1531 1434-6621 41:11<1525 2003 41 cclm https://doi.org/10.1515/CCLM.2003.234 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.234 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herrmann Markus aut NATIONALLICENCE 700 1- Wilkinson John aut NATIONALLICENCE 700 1- Schorr Heike aut NATIONALLICENCE 700 1- Obeid Rima aut NATIONALLICENCE 700 1- Georg Thomas aut NATIONALLICENCE 700 1- Urhausen Axel aut NATIONALLICENCE 700 1- Scharhag Jürgen aut NATIONALLICENCE 700 1- Kindermann Wilfried aut NATIONALLICENCE 700 1- Herrmann Wolfgang aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1525-1531 1434-6621 41:11<1525 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter