caa a22 4500 37885237X CHVBK 20180305123326.0 cr unu---uuuuu 161128e20031117xx s 000 0 eng 10.1515/CCLM.2003.232 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.232 The Impact of Hyperhomocysteinemia as a Cardiovascular Risk Factor in the Prediction of Coronary Heart Disease [Elektronische Daten] [Jürgen Geisel, Benno Hennen, Ulrich Hübner, Jean-Pierre Knapp, Wolfgang Herrmann] Coronary heart disease often occurs in the absence of traditional risk factors. Consequently, epidemiological studies exploring novel risk factors are necessary to improve the prediction of coronary heart disease. This study evaluated five promising markers of cardiovascular risk: homocysteine, C-reactive protein, fibrinogen, lipoprotein(a) (Lp(a)), free apolipoprotein(a) (apo(a)) and Lp(a) phenotypes. The study included 135 patients with angiographically confirmed atherosclerosis. The control group consisted of 93 sex- and age-matched individuals. The Mann-Whitney U-test was used for group comparison. New risk factors were evaluated by binary logistic regression. The odds ratios were calculated continuously for homocysteine in dependence on C-reactive protein. Low density lipoprotein (LDL)-cholesterol was nearly identical in controls and patients. Homocysteine, C-reactive protein, fibrinogen, high density lipoprotein (HDL)-cholesterol and Lp(a) discriminated highly significantly between both groups. The continuously calculated odds ratio for homocysteine demonstrated a distinct influence of C-reactive protein. In the group with high C-reactive protein levels, homocysteine levels above 9.6 μmol/l resulted in a markedly elevated risk (odds ratio 12), in the group with C-reactive protein levels below 5 mg/dl, a comparable risk increase was observed at a homocysteine level of 16.6 μmol/l. This data strongly suggests that plasma homocysteine helps identify individuals at risk, especially among those with elevated C-reactive protein levels. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Geisel Jürgen aut Hennen Benno aut Hübner Ulrich aut Knapp Jean-Pierre aut Herrmann Wolfgang aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1513-1517 1434-6621 41:11<1513 2003 41 cclm https://doi.org/10.1515/CCLM.2003.232 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.232 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geisel Jürgen aut NATIONALLICENCE 700 1- Hennen Benno aut NATIONALLICENCE 700 1- Hübner Ulrich aut NATIONALLICENCE 700 1- Knapp Jean-Pierre aut NATIONALLICENCE 700 1- Herrmann Wolfgang aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/11(2003-11-17), 1513-1517 1434-6621 41:11<1513 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter