caa a22 4500 378852876 CHVBK 20180305123328.0 cr unu---uuuuu 161128e200308 xx s 000 0 eng 10.1515/pteridines.2003.14.3.102 doi (NATIONALLICENCE)gruyter-10.1515/pteridines.2003.14.3.102 Follow-up of Urinary Neopterin Concentrations in two Healthy Children until Adolescence [Elektronische Daten] [Christiana Winkler, Barbara Frick, Katharina Schroecksnadel, Barbara Wirleitner, Dietmar Fuchs] Neopterin is a sensitive marker of the activated cellular (= Thl-type) immune response. Neopterin concentrations in healthy children are higher compared with those of adults and are declining with increasing age. In this study, we present a follow-up of urinary neopterin to creatinine concentrations in two healthy children until adolescence. Data were available from one female (7 - 23 years) and her brother (0 - 18 years), of whom early morning urine specimens were collected on an irregular basis throughout 18 years. In total, neopterin and creatinine concentrations were measured by high pressure liquid chromatography (HPLC) in 343 urinary specimens. In both children, concentrations of urinary neopterin were highest at study entry. With increasing age neopterin concentrations decreased continuously to reach rather constant levels around the age of fifteen years. On several occasions at which individuals presented with common sickness, mostly of infectious origin, neopterin concentrations were found highly increased. In the absence of such infectious episodes, neopterin/creatinine measurements of both individuals fit well to previously established normal ranges. However this was true only for specimens collcctcd when children were older than 10 years, before that age concentrations of neopterin were frequently found to be higher than the established upper limits of the normal range. © 2013 by Walter de Gruyter GmbH & Co. neopterin nationallicence healthy controls nationallicence urine nationallicence Winkler Christiana Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut Frick Barbara Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut Schroecksnadel Katharina Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut Wirleitner Barbara Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut Fuchs Dietmar Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut Pteridines De Gruyter 14/3(2003-08), 102-107 0933-4807 14:3<102 2003 14 pteridines https://doi.org/10.1515/pteridines.2003.14.3.102 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/pteridines.2003.14.3.102 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winkler Christiana Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut NATIONALLICENCE 700 1- Frick Barbara Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut NATIONALLICENCE 700 1- Schroecksnadel Katharina Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut NATIONALLICENCE 700 1- Wirleitner Barbara Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut NATIONALLICENCE 700 1- Fuchs Dietmar Institute for Medical Chemistry and Biochemistry, University of Innsbruck aut NATIONALLICENCE 773 0- Pteridines De Gruyter 14/3(2003-08), 102-107 0933-4807 14:3<102 2003 14 pteridines CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter