caa a22 4500 378852892 CHVBK 20180305123328.0 cr unu---uuuuu 161128e200308 xx s 000 0 eng 10.1515/pteridines.2003.14.3.82 doi (NATIONALLICENCE)gruyter-10.1515/pteridines.2003.14.3.82 Homocysteine, Β Vitamins and Immune Activation in Coronary Heart Disease [Elektronische Daten] [Barbara Frick, Vera Rudzite, Katharina Schröcksnadel, Uldis Kalnins, Andrejs Erglis, Karlis Trusinskis, Dietmar Fuchs] Moderate hyperhomocysteinemia is associated with an increased risk of coronary heart disease (CHD). An inverse relationship usually exists between homocysteine and folate concentrations, and folate supplementation is often able to lower homocysteine concentrations. Thus, insufficient dietary intake of folate and/or vitamin B12 is considered to be responsible for the development of hyperhomocysteinemia. Inflammation and immune activation appear also to be important in the pathogenesis of CHD and may influence availability of folate. Blood concentrations of homocysteine, Β vitamins and neopterin were examined in 35 patients with CHD verified by coronary angiography, (2 1 patients with one-artery disease, 9 with two- or three-artery disease, 5 with restenosis). Compared to 30 healthy controls, a significant proportion of patients presented with increased homocysteine concentrations. Hyperhomocysteinemia coincided with lower folate and also with higher neopterin concentrations indicating immune system activation. In addition, correlations existed between neopterin and homocysteine (r = 0.472, ρ < 0.01) and folate (r = -0.370, ρ = 0.01). We conclude that higher homocysteine is not only associated with lower circulating folate but also with higher neopterin. Immune activation could be involved to cause an increased demand for folate resulting in hyperhomocysteinemia even when dietary folate intake is within the recommended range. © 2013 by Walter de Gruyter GmbH & Co. coronary heart disease nationallicence homocysteine nationallicence neopterin nationallicence Frick Barbara Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut Rudzite Vera Latvian Institute of Cardiology, Riga, Latvia aut Schröcksnadel Katharina Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut Kalnins Uldis Latvian Institute of Cardiology, Riga, Latvia aut Erglis Andrejs Latvian Institute of Cardiology, Riga, Latvia aut Trusinskis Karlis Latvian Institute of Cardiology, Riga, Latvia aut Fuchs Dietmar Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut Pteridines De Gruyter 14/3(2003-08), 82-87 0933-4807 14:3<82 2003 14 pteridines https://doi.org/10.1515/pteridines.2003.14.3.82 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/pteridines.2003.14.3.82 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frick Barbara Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 700 1- Rudzite Vera Latvian Institute of Cardiology, Riga, Latvia aut NATIONALLICENCE 700 1- Schröcksnadel Katharina Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 700 1- Kalnins Uldis Latvian Institute of Cardiology, Riga, Latvia aut NATIONALLICENCE 700 1- Erglis Andrejs Latvian Institute of Cardiology, Riga, Latvia aut NATIONALLICENCE 700 1- Trusinskis Karlis Latvian Institute of Cardiology, Riga, Latvia aut NATIONALLICENCE 700 1- Fuchs Dietmar Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 773 0- Pteridines De Gruyter 14/3(2003-08), 82-87 0933-4807 14:3<82 2003 14 pteridines CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter