caa a22 4500 378852906 CHVBK 20180305123328.0 cr unu---uuuuu 161128e200308 xx s 000 0 eng 10.1515/pteridines.2003.14.3.77 doi (NATIONALLICENCE)gruyter-10.1515/pteridines.2003.14.3.77 Neopterin Profile to Evaluate the Effectiveness of Treatment in Aggressive Periodontitis [Elektronische Daten] [Aysen Bodur, Terken Baydar, Nurdan Ozmeric, Ayse Basak Engin, Ahu Uraz, Kaya Eren, Gonul Sahin] Periodontal disease results from the interaction of the host defence mechanisms with the microbial dental plaque. Analysis of gingival crevicular Huid (GCF) provides a non-invasive means of evaluating the role of the host response in periodontal disease. Based on our previous study, demonstrating increased levels of neopterin in GCF and saliva from patients with aggressive periodontitis (AgP), the aim of this study was to evaluate the effect of periodontal treatment on the levels of neopterin in GCF, saliva and urine of patients with AgP. Pre-treatment values of neopterin in GCF were 4.04 ± 0.86 nmol/ml for the AgP group (n=8) and 2.68 ± 0.90 nmol/ml fyr the control group (n=8; difference not significant). After periodontal treatment, the level of ncoptei in was found 2.38 ± 0.72 nmol/ml in the patient group which did not differ f r om pre-treatment levels. The salivary neopterin concentration was higher in both AgP groups (14.14 ± 2.85 nmol/1 and 8.02 ± 3.12 nmol/1, before and after periodontal treatment) than in controls (2.58 ± 0.3 nmol/1; both p<0.05). No significant difference in salivary neopterin level was observed in patients before and after periodontal treatment. Concentrations of urine neopterin in patients before treatment were 188.5 ± 30.98 μηιοί neopterin/mol creatinine and 168.1 + 20.21 μηιοί in controls (difference not significant). Following periodontal treatment, the urinary neopterin levels (310.1 ± 39.82 μηιοί neopterin/mol creatinine) were higher when compared to the baseline levels and to controls (p<0.05). Our results suggest that neopterin in saliva and GCF might be associated with the periodontal diseases process. © 2013 by Walter de Gruyter GmbH & Co. neopterin nationallicence gingival crevicular fluid nationallicence saliva nationallicence urine nationallicence aggressive periodontitis nationallicence Bodur Aysen Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut Baydar Terken Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut Ozmeric Nurdan Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut Engin Ayse Basak Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut Uraz Ahu Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut Eren Kaya Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut Sahin Gonul Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut Pteridines De Gruyter 14/3(2003-08), 77-81 0933-4807 14:3<77 2003 14 pteridines https://doi.org/10.1515/pteridines.2003.14.3.77 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/pteridines.2003.14.3.77 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bodur Aysen Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut NATIONALLICENCE 700 1- Baydar Terken Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut NATIONALLICENCE 700 1- Ozmeric Nurdan Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut NATIONALLICENCE 700 1- Engin Ayse Basak Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut NATIONALLICENCE 700 1- Uraz Ahu Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut NATIONALLICENCE 700 1- Eren Kaya Department of Peri odontology, Faculty of Dentistry, Gazi University, 06510 Ankara, Turkey aut NATIONALLICENCE 700 1- Sahin Gonul Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey aut NATIONALLICENCE 773 0- Pteridines De Gruyter 14/3(2003-08), 77-81 0933-4807 14:3<77 2003 14 pteridines CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter