caa a22 4500 378852914 CHVBK 20180305123328.0 cr unu---uuuuu 161128e200308 xx s 000 0 eng 10.1515/pteridines.2003.14.3.94 doi (NATIONALLICENCE)gruyter-10.1515/pteridines.2003.14.3.94 Effects of Carnosine on the Toxicity of Doxorubicin in Rabbits and Mice [Elektronische Daten] [Remigiusz Zieba, Elzbieta Czarnecka, Małgorzata Wągrowska-Danilewicz, Malgorzata Dzielska-Olczak, Julita Graczyk] The aim of this study was to establish the effect of naturally occurring antioxidant - carnosine - on the doxorubicin induced cardiotoxicity in a rabbit model. For this purpose we evaluated the influence of doxorubicin administration alone and in a combined therapy with carnosine on the haemodynamic parameters and on the degree of cardiac muscle cells alterations in rabbits. The rabbits were divided into four groups. One group of rabbits was injccted with doxorubicin in a dose of 2 mg kg-1 weekly for 7 weeks to induce congestive heart failure. Another group of rabbits received the same doses of doxorubicin simultaneously with carnosine in a dose of 100 mg kg1 p.o. daily for 9 weeks. Administration of carnosine was started 1 week prior to the first dose of doxorubicin and was ended one week after the administration of the last dose of doxorubicin. The control groups of animals received 0.9% NaCl and carnosine alone. The following haemodynamic parameters were estimated: heart rate, mean arterial pressure, cardiac index, stroke index and total peripheral resistance. Registration of the haemodynamic parameters in rabbits was performed by Doppler method. Carnosine normalised the values of mean arterial pressure in rabbits receiving doxorubicin, and increased the values of cardiac index and stroke index. The influence of carnosine on total peripheral resistance was not statistically significant, but there was a decreasing tendency. The degree of cardiac muscle cell alterations was examined by light microscopy using Mean Total Score technique. The histopathological studies revealed smaller damage of cardiac muscle in rabbits which received doxorubicin and carnosine, in comparison to animals receiving doxorubicin alone. Carnosine seems to be car dioprotective during doxorubicin administration © 2013 by Walter de Gruyter GmbH & Co. doxorubicin nationallicence cardiotoxicity nationallicence haemodynamic parameters nationallicence histopathological changes nationallicence carnosine nationallicence cardioprotection nationallicence Zieba Remigiusz Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut Czarnecka Elzbieta Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut Wągrowska-Danilewicz Małgorzata Department of Pathomorphology, Medical University of Lodz. Czechoslowacka 8/10. Poland aut Dzielska-Olczak Malgorzata Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut Graczyk Julita Department of Pharmacology, Medical University of Lodz, Muszyñskiego 1, Poland aut Pteridines De Gruyter 14/3(2003-08), 94-101 0933-4807 14:3<94 2003 14 pteridines https://doi.org/10.1515/pteridines.2003.14.3.94 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/pteridines.2003.14.3.94 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zieba Remigiusz Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut NATIONALLICENCE 700 1- Czarnecka Elzbieta Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut NATIONALLICENCE 700 1- Wągrowska-Danilewicz Małgorzata Department of Pathomorphology, Medical University of Lodz. Czechoslowacka 8/10. Poland aut NATIONALLICENCE 700 1- Dzielska-Olczak Malgorzata Department of Pharmacodynamics, Medical University of Lodz. Muszyñskiego 1, Poland aut NATIONALLICENCE 700 1- Graczyk Julita Department of Pharmacology, Medical University of Lodz, Muszyñskiego 1, Poland aut NATIONALLICENCE 773 0- Pteridines De Gruyter 14/3(2003-08), 94-101 0933-4807 14:3<94 2003 14 pteridines CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter