Molecular and Functional Interdependence of the Urokinase-Type Plasminogen Activator System with Integrins
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| 024 | 7 | 0 | |a 10.1515/BC.2003.125 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2003.125 | ||
| 245 | 0 | 0 | |a Molecular and Functional Interdependence of the Urokinase-Type Plasminogen Activator System with Integrins |h [Elektronische Daten] |c [U. Reuning, V. Magdolen, S. Hapke, M. Schmitt] |
| 520 | 3 | |a The serine protease urokinase-type plasminogen activator (uPA), its inhibitor PAI-1, and its cellular receptor uPA-R (CD87) are of crucial importance during cellular invasion and migration, required for a variety of physio- and pathophysiological processes. It has become increasingly evident in recent years that the uPA/uPA-R-system has far more functional properties than plasminogen activation alone. This is reflected by its involvement in cellular events such as proliferation, adhesion, migration, and chemotaxis. Since uPA-R lacks a transmembrane domain and thus on its own is not capable of transmitting signals into cells, association and functional cooperation with other signaling molecules/receptors is needed. In this respect, one group of adhesion and signaling receptors, the integrins, have been identified which constitute, together with the uPA/uPA-R-system, an interdependent biological network by which the uPA/uPA-R-system broadly affects integrin functions and vice versa. Moreover, there is a growing body of evidence that cellular uPA, uPA-R, and PAI-1 expression is under control of specific ECM/integrin interactions and also that integrins are regulated by components of the uPA/uPARsystem. By this multifaceted crosstalk, cells may modulate their proteolytic, adhesive, and migratory activities and monitor ECM integrity in their microenvironment. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 700 | 1 | |a Reuning |D U. |4 aut | |
| 700 | 1 | |a Magdolen |D V. |4 aut | |
| 700 | 1 | |a Hapke |D S. |4 aut | |
| 700 | 1 | |a Schmitt |D M. |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 384/8(2003-08-20), 1119-1131 |x 1431-6730 |q 384:8<1119 |1 2003 |2 384 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2003.125 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2003.125 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Reuning |D U. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Magdolen |D V. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hapke |D S. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schmitt |D M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 384/8(2003-08-20), 1119-1131 |x 1431-6730 |q 384:8<1119 |1 2003 |2 384 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||