caa a22 4500 378853074 CHVBK 20180305123328.0 cr unu---uuuuu 161128e20030820xx s 000 0 eng 10.1515/BC.2003.125 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.125 Molecular and Functional Interdependence of the Urokinase-Type Plasminogen Activator System with Integrins [Elektronische Daten] [U. Reuning, V. Magdolen, S. Hapke, M. Schmitt] The serine protease urokinase-type plasminogen activator (uPA), its inhibitor PAI-1, and its cellular receptor uPA-R (CD87) are of crucial importance during cellular invasion and migration, required for a variety of physio- and pathophysiological processes. It has become increasingly evident in recent years that the uPA/uPA-R-system has far more functional properties than plasminogen activation alone. This is reflected by its involvement in cellular events such as proliferation, adhesion, migration, and chemotaxis. Since uPA-R lacks a transmembrane domain and thus on its own is not capable of transmitting signals into cells, association and functional cooperation with other signaling molecules/receptors is needed. In this respect, one group of adhesion and signaling receptors, the integrins, have been identified which constitute, together with the uPA/uPA-R-system, an interdependent biological network by which the uPA/uPA-R-system broadly affects integrin functions and vice versa. Moreover, there is a growing body of evidence that cellular uPA, uPA-R, and PAI-1 expression is under control of specific ECM/integrin interactions and also that integrins are regulated by components of the uPA/uPARsystem. By this multifaceted crosstalk, cells may modulate their proteolytic, adhesive, and migratory activities and monitor ECM integrity in their microenvironment. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Reuning U. aut Magdolen V. aut Hapke S. aut Schmitt M. aut Biological Chemistry Walter de Gruyter 384/8(2003-08-20), 1119-1131 1431-6730 384:8<1119 2003 384 bchm https://doi.org/10.1515/BC.2003.125 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.125 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reuning U. aut NATIONALLICENCE 700 1- Magdolen V. aut NATIONALLICENCE 700 1- Hapke S. aut NATIONALLICENCE 700 1- Schmitt M. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/8(2003-08-20), 1119-1131 1431-6730 384:8<1119 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter