caa a22 4500 378853511 CHVBK 20180305123329.0 cr unu---uuuuu 161128e20031204xx s 000 0 eng 10.1515/CCLM.2003.239 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.239 The Application of Clinical Proteomics to Cancer and other Diseases [Elektronische Daten] [William Clarke, Zhen Zhang, Daniel W. Chan] The term "clinical proteomics” refers to the application of available proteomics technologies to current areas of clinical investigation. The ability to simultaneously and comprehensively examine changes in large numbers of proteins in the context of disease or other changes in physiological conditions holds great promise as a tool to unlock the solutions to difficult clinical research questions. Proteomics is a rapidly growing field that combines high throughput analytical methodologies such as two-dimensional gel electrophoresis and SELDI mass spectrometry methods with complex bioinformatics to study systems biology-the system of interest is defined by the investigator. Even with all its potential, however, studies must be carefully designed in order to differentiate true clinical differences in protein expression from differences originating from variation in sample collection, variation in experimental condition, and normal biological variability. Proteomic analyses are already widely in use for clinical studies ranging from cancer to other diseases such as cardiovascular disease, organ transplant, and pharmacodynamic studies. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Clarke William aut Zhang Zhen aut Chan Daniel W. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/12(2003-12-04), 1562-1570 1434-6621 41:12<1562 2003 41 cclm https://doi.org/10.1515/CCLM.2003.239 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.239 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clarke William aut NATIONALLICENCE 700 1- Zhang Zhen aut NATIONALLICENCE 700 1- Chan Daniel W. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/12(2003-12-04), 1562-1570 1434-6621 41:12<1562 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter