caa a22 4500 378858866 CHVBK 20180305123341.0 cr unu---uuuuu 161128e20031107xx s 000 0 eng 10.1515/BC.2003.156 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.156 Yonath A. Ribosomal Tolerance and Peptide Bond Formation [Elektronische Daten] [A. Yonath] In the ribosome, the decoding and peptide bond formation sites are composed entirely of ribosomal RNA, thus confirming that the ribosome is a ribozyme. Precise alignment of the aminoacylated and peptidyl tRNA 3'-ends, which is the major enzymatic contribution of the ribosome, is dominated by remote interactions of the tRNA double helical acceptor stem with the distant rims of the peptidyl transferase center. An elaborate architecture and a sizable symmetryrelated region within the otherwise asymmetric ribosome guide the A > P passage of the tRNA 3'-end by a spiral rotatory motion, and ensures its outcome: stereochemistry suitable for peptide bond formation and geometry facilitating the entrance of newly formed proteins into their exit tunnel. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1411-1419 1431-6730 384:10-11<1411 2003 384 bchm https://doi.org/10.1515/BC.2003.156 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.156 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Yonath A. NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1411-1419 1431-6730 384:10-11<1411 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter