caa a22 4500 378858882 CHVBK 20180305123341.0 cr unu---uuuuu 161128e20031107xx s 000 0 eng 10.1515/BC.2003.154 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.154 Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators [Elektronische Daten] [A. Huwiler, J. Pfeilschifter] The ways in which cells communicate among each other concerns all aspects of biology, from developmental processes to diseases. Nitric oxide (NO) is one of the most remarkable and unusual regulatory molecules. It is a labile free radical gas that is not stored but generated on demand, and has been implicated in an extraordinarily diverse range of physiological and pathophysiological functions. The modulation of cell signalling by free radicals is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing microenvironment. In a multicellular organism this serves to coordinate complex physiological responses, such as inflammation. Cell signalling is also accompanied by rapid remodelling of membrane lipids by activated lipases. The discovery that NO, which does not reversibly interact with membrane receptors like conventional hormones and growth factors, targets enzymes such as phospholipase A2, sphingomyelinases or ceramidases, has stimulated growing interest in the crosstalk between redox and lipid signalling. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Huwiler A. aut Pfeilschifter J. aut Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1379-1389 1431-6730 384:10-11<1379 2003 384 bchm https://doi.org/10.1515/BC.2003.154 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huwiler A. aut NATIONALLICENCE 700 1- Pfeilschifter J. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1379-1389 1431-6730 384:10-11<1379 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter