caa a22 4500 378858955 CHVBK 20180305123341.0 cr unu---uuuuu 161128e20031107xx s 000 0 eng 10.1515/BC.2003.165 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.165 Aptamers That Recognize the Lipid Moiety of the Antibiotic Moenomycin A [Elektronische Daten] [H. Betat, S. Vogel, M. Struhalla, H.-H. Förster, M. Famulok, P. Welzel, U. Hahn] Moenomycin A is an amphiphilic phosphoglycolipid antibiotic that interferes with the transglycosylation step in peptidoglycan biosynthesis. The antibiotic consists of a branched pentasaccharide moiety, connected to the moenocinol lipid via a glycerophosphate linker. We have previously described the selection of aptamers that require the lipid group and the disaccharide epitopes of the oligosaccharide moiety for moenomycin-binding. Here we report that the enriched moenomycinbinding library contains sequences that evolved for specific recognition of the unpolar lipid group of the antibiotic. These results suggest that the evolution of hydrophobic binding pockets in RNA molecules may be much more common than previously assumed. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Betat H. aut Vogel S. aut Struhalla M. aut Förster H.-H aut Famulok M. aut Welzel P. aut Hahn U. aut Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1497-1500 1431-6730 384:10-11<1497 2003 384 bchm https://doi.org/10.1515/BC.2003.165 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.165 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Betat H. aut NATIONALLICENCE 700 1- Vogel S. aut NATIONALLICENCE 700 1- Struhalla M. aut NATIONALLICENCE 700 1- Förster H.-H aut NATIONALLICENCE 700 1- Famulok M. aut NATIONALLICENCE 700 1- Welzel P. aut NATIONALLICENCE 700 1- Hahn U. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1497-1500 1431-6730 384:10-11<1497 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter