caa a22 4500 378859005 CHVBK 20180305123341.0 cr unu---uuuuu 161128e20031107xx s 000 0 eng 10.1515/BC.2003.152 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.152 Regulation of the Expression of Inducible Nitric Oxide Synthase [Elektronische Daten] [H. Kleinert, P. M. Schwarz, U. Förstermann] Nitric oxide (NO), generated by the inducible isoform of nitric oxide synthase (iNOS), has been described to have beneficial microbicidal, antiviral, antiparasital, immunomodulatory, and antitumoral effects. However, aberrant iNOS induction at the wrong place or at the wrong time has detrimental consequences and seems to be involved in the pathophysiology of several human diseases. iNOS is primarily regulated at the expression level by transcriptional and posttranscriptional mechanisms. iNOS expression can be induced in many cell types with suitable agents such as bacterial lipopolysaccharides (LPS), cytokines, and other compounds. Pathways resulting in the induction of iNOS expression may vary in different cells or different species. Activation of the transcription factors NF-κB and STAT-1α, and thereby activation of the iNOS promoter, seems to be an essential step for iNOS induction in most cells. However, at least in the human system, also post-transcriptional mechanism are critically involved in the regulation of iNOS expression. The induction of iNOS can be inhibited by a wide variety of immunomodulatory compounds acting at the transcriptional levels and/or post-transcriptionally. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Kleinert H. aut Schwarz P. M. aut Förstermann U. aut Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1343-1364 1431-6730 384:10-11<1343 2003 384 bchm https://doi.org/10.1515/BC.2003.152 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.152 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kleinert H. aut NATIONALLICENCE 700 1- Schwarz P. M. aut NATIONALLICENCE 700 1- Förstermann U. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1343-1364 1431-6730 384:10-11<1343 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter