caa a22 4500 378859021 CHVBK 20180305123342.0 cr unu---uuuuu 161128e20031107xx s 000 0 eng 10.1515/BC.2003.167 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.167 Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors [Elektronische Daten] [C. Le Page, J. Wietzerbin] ADP-ribosylation is involved in nuclear factor κB (NF-κB)-dependent gene expression induced by lipopolysaccharide in murine macrophages. Here we have investigated the mechanism by which ADP-ribosylation inhibitors block signaling pathways induced in macrophages. In RAW264.7 macrophages the inducers of NF-κB activate the production of reactive oxygen species and three mitogenactivated protein kinases (MAPK), the extracellular signal regulated kinase (ERK), the c-jun N-terminal kinase/stress-activated protein kinase (JNK), and p38. We demonstrate that ADP-ribosylation inhibitors specifically inhibit ERK MAPK activation and reduce the release of inflammatory mediators such as tumor necrosis factor α (TNF-α), IL-6 and nitrite. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Page C. Le aut Wietzerbin J. aut Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1509-1513 1431-6730 384:10-11<1509 2003 384 bchm https://doi.org/10.1515/BC.2003.167 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.167 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Page C. Le aut NATIONALLICENCE 700 1- Wietzerbin J. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/10-11(2003-11-07), 1509-1513 1431-6730 384:10-11<1509 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter