caa a22 4500 378861344 CHVBK 20180305123347.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375111771 doi (NATIONALLICENCE)gruyter-10.1351/pac200375111771 Nuclear receptor action involved with sex differentiation [Elektronische Daten] [I. A. Hughes, Howard Martin, Jarmo Jääskeläinen, C. L. Acerini] Sex determination and differentiation in the male is an orderly sequence of events coordinated by genetic and hormonal factors operating in a time- and concentration-dependent manner. The constitutive sex in mammals is female. Disorders of fetal sex development have provided the means to identify testis-determining genes and the molecular mechanisms of hormone action. Thus, the androgen receptor, a nuclear hormone receptor critical for androgen-induced male sex differentiation, displays unique intra-receptor and protein-protein interactions which, when disturbed, can result in extreme forms of sex reversal. Polymorphic variants are associated with milder disorders of sex development. Against this genetic background, endocrine active substances may further contribute to the underlying causes of an increase in male reproductive tract disorders. © 2013 Walter de Gruyter GmbH, Berlin/Boston Hughes I. A. Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut Martin Howard Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut Jääskeläinen Jarmo Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut Acerini C. L. Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1771-1784 0033-4545 75:11-12<1771 2003 75 pac https://doi.org/10.1351/pac200375111771 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375111771 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hughes I. A. Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 700 1- Martin Howard Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 700 1- Jääskeläinen Jarmo Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 700 1- Acerini C. L. Department of Paediatrics, University of Cambridge, Addenbrooke 's Hospital, Box 116, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1771-1784 0033-4545 75:11-12<1771 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter