Enhanced one-generation reproductive toxicity study in rats for detecting endocrine-disrupting effects of chemicals
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| 024 | 7 | 0 | |a 10.1351/pac200375112497 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200375112497 | ||
| 245 | 0 | 0 | |a Enhanced one-generation reproductive toxicity study in rats for detecting endocrine-disrupting effects of chemicals |h [Elektronische Daten] |c [H. Aoyama, K. Suzuki] |
| 520 | 3 | |a An enhanced one-generation reproductive toxicity study in rats without adjusting a litter size during the lactation period is proposed as a rapid and reliable bioassay for providing the data concerning adverse and/or low-dose effects of suspected endocrine disruptors. In this study, pregnant females are treated with the test substance from gestation day 0 through lactation day 21, in principle. F1 offspring from one-half of the litters in each dose group are killed and necropsied at weaning, while those from the remaining litters are examined for sexual maturation, estrous cyclicity, and/or sperm production. A series of pilot studies with ethynylestradiol as a reference chemical have suggested that the exposure of estrogenic chemicals during the early gestation period is critical for detecting effects on fertilization and/or implantation of eggs and survival of implants, and that expression of some genes including AR in the prostate and IGF-1 in the uterus of F1 offspring may be sensitive markers for monitoring potential estrogenic effects of the test compound. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Aoyama |D H. |u Laboratory of Reproductive Toxicology, Institute of Environmental Toxicology, Japan; Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Japan |4 aut | |
| 700 | 1 | |a Suzuki |D K. |u Laboratory of Reproductive Toxicology, Institute of Environmental Toxicology, Japan; Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Japan |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 75/11-12(2003-01-01), 2497-2501 |x 0033-4545 |q 75:11-12<2497 |1 2003 |2 75 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200375112497 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200375112497 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aoyama |D H. |u Laboratory of Reproductive Toxicology, Institute of Environmental Toxicology, Japan; Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suzuki |D K. |u Laboratory of Reproductive Toxicology, Institute of Environmental Toxicology, Japan; Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 75/11-12(2003-01-01), 2497-2501 |x 0033-4545 |q 75:11-12<2497 |1 2003 |2 75 |o pac | ||
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||