caa a22 4500 378861433 CHVBK 20181011064632.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112435 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112435 Segner H. Centre for Fish and Wildlife Health, University of Bern, Post Box, CH-3001 Bern, Switzerland Need for establishing integrated programs to monitor endocrine active compounds [Elektronische Daten] [H. Segner] Environmental monitoring programs on endocrine active compounds (EACs) have been used to document the level of exposure and to assess the possible association to the occurrence of developmental and reproductive disorders in wildlife. The establishment of causal links between exposure and effect data, however, was found to be difficult due to, for example, the presence of confounding factors or limited understanding of EAC mechanisms and interactions, but also because of conceptual and methodological limitations of current monitoring strategies. In order to provide plausibility of an EAC etiology for a developmental or reproductive alteration in a wildlife population, integrated monitoring programs are needed that will use a combination of complementary approaches: methods for a targeted search for suspected EACs in an environmental mixture, analysis of internal EAC doses instead of external EAC concentrations, utilization of mechanism-based end-points in bioanalytical and effect monitoring, investigation of the basic biology and physiology of wildlife sentinel species, laboratory replication of field effects, as well as consideration of epidemiological and weight-of-evidence criteria in the design and data evaluation of monitoring programs. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2435-2444 0033-4545 75:11-12<2435 2003 75 pac https://doi.org/10.1351/pac200375112435 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112435 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Segner H. Centre for Fish and Wildlife Health, University of Bern, Post Box, CH-3001 Bern, Switzerland NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2435-2444 0033-4545 75:11-12<2435 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence SWISSBIB 378861433 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter