caa a22 4500 378861573 CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375111843 doi (NATIONALLICENCE)gruyter-10.1351/pac200375111843 Holland P. T. Cawthron Institute, 98 Halifax Street E, Nelson, New Zealand Analysis of endocrine active substances in food and the environment [Elektronische Daten] [P. T. Holland] A critical review is made of techniques for analysis of residues of endocrine active substances (EASs) including sampling, extraction cleanup and determination based on GC/MS, LC/MS, ELISA, and bioassays. The growing importance of receptor-based in vitro bioassays is highlighted for integrated monitoring of environmental levels of certain classes of EASs and for establishing exposures. Some recent advances in methods of analysis for each of the key classes of EASs are summarized including for organochlorines, PCBs, dioxins and dioxin-like substances, polybrominated diphenyl ethers, phenolic xenoestrogens, phthalates, organotin compounds, steroidal hormones, and phytoestrogens. The issues raised in interpreting complementary chemical and bioassay data at an effects level are briefly discussed. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1843-1857 0033-4545 75:11-12<1843 2003 75 pac https://doi.org/10.1351/pac200375111843 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375111843 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Holland P. T. Cawthron Institute, 98 Halifax Street E, Nelson, New Zealand NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1843-1857 0033-4545 75:11-12<1843 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter