caa a22 4500 37886159X CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112461 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112461 Routledge E. J. Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, UB8 3PH,UK Identifying the causative agents: The use of combined chemical and biological strategies in monitoring programs [Elektronische Daten] [E. J. Routledge] The toxicity identification and evaluation (TIE) approach that identified unconjugated natural and synthetic steroid estrogens to be the major estrogenic component in domestic sewage treatment work effluent is described. Given the increasing popularity of TIE-based approaches in ecotoxicology research, a number of important considerations, limitations, and possible future directions of TIE studies are also discussed. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2461-2466 0033-4545 75:11-12<2461 2003 75 pac https://doi.org/10.1351/pac200375112461 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112461 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Routledge E. J. Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, UB8 3PH,UK NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2461-2466 0033-4545 75:11-12<2461 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter