caa a22 4500 378861670 CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112415 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112415 Temporal responses to estrogen in the uterus [Elektronische Daten] [K. C. Fertuck, T. R. Zacharewski] The estrogen receptor acts primarily as an estrogen-inducible transcription factor in target organs, however, until recently the identification of individual responsive transcripts has been cumbersome. In the present study, oligonucleotide GeneChip microarrays were used to describe and analyze the levels of approximately 6500 transcripts in the uteri of immature, ovariectomized mice at various times following oral exposure to 100 μg/kg of ethynyl estradiol. The most reproducible responses were identified and subjected to K-means clustering, and functional annotations were obtained for the transcripts within each cluster. Connections were made between the observed transcriptional responses and the known physiological responses to estrogen exposure, focusing here on effects on uterine cell cycle progression leading to estrogen-stimulated uterine growth. © 2013 Walter de Gruyter GmbH, Berlin/Boston Fertuck K. C. Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1319, USA aut Zacharewski T. R. Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1319, USA aut Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2415-2418 0033-4545 75:11-12<2415 2003 75 pac https://doi.org/10.1351/pac200375112415 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112415 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fertuck K. C. Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1319, USA aut NATIONALLICENCE 700 1- Zacharewski T. R. Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1319, USA aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2415-2418 0033-4545 75:11-12<2415 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter