caa a22 4500 378861735 CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375111665 doi (NATIONALLICENCE)gruyter-10.1351/pac200375111665 Nuclear receptor coregulators [Elektronische Daten] [N. J. McKenna, B. W. O'Malley] It has been postulated that nuclear receptors (NRs) regulate transcription via interactions with chromatin and the basal transcription machinery at the promoters of genes. Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulating positive or negative receptor activity. A large number of putative coactivators have been isolated, several of which will be reviewed with respect to certain "criteria" initially proposed for coactivators. We will discuss, with reference to in vitro and in vivo experiments, the main steps in initiation that are influenced by coactivators: (1) initiation (e.g., SRC-1 family, CBP); (2) repetitive transcription (e.g., TRAPs/DRIPs); (3) RNA processing (PGC-1, etc); and (4) termination/turnover (E6-AP, etc). A variety of enzyme functions have been implicated in the coactivator complex including acetylase, methylase, ubiquitin ligase, kinase, and phosphatase activities. Moreover, coactivators and corepressors appear to exist in the steady-state cell as a series of multiprotein complexes referred to collectively as the "coregulatorsome". Different subcomplexes within the coregulatorsome may have different levels of preference for individual receptors or promoters, likely contributing to context-specific functions of NRs in target tissues. © 2013 Walter de Gruyter GmbH, Berlin/Boston McKenna N. J. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA aut O'Malley B. W. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA aut Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1665-1669 0033-4545 75:11-12<1665 2003 75 pac https://doi.org/10.1351/pac200375111665 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375111665 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McKenna N. J. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA aut NATIONALLICENCE 700 1- O'Malley B. W. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 1665-1669 0033-4545 75:11-12<1665 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter