caa a22 4500 378861778 CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112419 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112419 Application of toxicogenomics to the endocrine disruption issue [Elektronische Daten] [T. Shirai, Makoto Asamoto] Toxicogenomics can be expected to be a useful method for detecting the carcinogenic potential of endocrine active substances (EASs) in the short term with the generation of understanding of mode-of-action and mechanisms when a reliable database with information about proteomics and informatics is established. At present, there are no concrete epidemiological data supporting any exogenous EAS contribution to hormone-related organ carcinogenesis in humans. However, with the establishment of appropriate animal models and analysis of genomic-scale gene expression, risk identification and evaluation should be facilitated within a relatively short period, and this approach eventually promises to contribute a great deal of risk management regarding EASs. © 2013 Walter de Gruyter GmbH, Berlin/Boston Shirai T. Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Nagoya 467-8601, Japan aut Asamoto Makoto Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Nagoya 467-8601, Japan aut Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2419-2422 0033-4545 75:11-12<2419 2003 75 pac https://doi.org/10.1351/pac200375112419 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112419 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shirai T. Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Nagoya 467-8601, Japan aut NATIONALLICENCE 700 1- Asamoto Makoto Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Nagoya 467-8601, Japan aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2419-2422 0033-4545 75:11-12<2419 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter