Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling
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| 024 | 7 | 0 | |a 10.1351/pac200375111743 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200375111743 | ||
| 100 | 1 | |a Picard |D D. |u Département de Biologie Cellulaire, Université de Genève, Sciences, III 30 quaiErnest-Ansermet, CH -1211 Genève 4, Switzerland | |
| 245 | 1 | 0 | |a Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling |h [Elektronische Daten] |c [D. Picard] |
| 520 | 3 | |a Signaling pathways can be linear, but more complex patterns are common. Growth factors and many other extracellular signals cannot directly enter cells and transduce their information via membrane-bound receptors. In contrast, steroid receptors are members of the nuclear receptor superfamily and await their cognate hormones inside the cells. These two types of signaling pathways are extensively intertwined and crosstalk at many different levels. A wide range of extra- and intracellular signals, including a variety of growth factors, can activate the transcriptional activity of steroid receptors in the absence of their cognate hormones. Conversely, steroid receptors lead a double life. By coupling to signaling molecules that mediate signal transduction of extracellular factors, they can elicit very rapid nongenomic responses. The signaling pathways of steroid-independent activation of steroid receptors, on the one hand, and of nongenomic signaling by steroid receptors, on the other, display a remarkable reciprocal relationship suggesting that these two modes of signaling crosstalk may be two faces of the same coin. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 75/11-12(2003-01-01), 1743-1756 |x 0033-4545 |q 75:11-12<1743 |1 2003 |2 75 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200375111743 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200375111743 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Picard |D D. |u Département de Biologie Cellulaire, Université de Genève, Sciences, III 30 quaiErnest-Ansermet, CH -1211 Genève 4, Switzerland | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 75/11-12(2003-01-01), 1743-1756 |x 0033-4545 |q 75:11-12<1743 |1 2003 |2 75 |o pac | ||