caa a22 4500 378861840 CHVBK 20180305123348.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112181 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112181 Environmental estrogens and sperm counts [Elektronische Daten] [Harry Fisch, Robert Golden] The term "environmental estrogen" refers to chemical substances that exhibit some degree of estrogen-like activity. The primary emphasis for potential adverse effects resulting from exposure to environmental estrogens is on in utero exposure because such exposure can occur during critical periods of organogenesis. Assessment of biological plausibility can be based, in part, on the extensive data on the effects of diethylstilbestrol (DES). The available evidence is too limited to judge with any confidence whether sperm counts have declined during the past 50 years. Based on both animal and human data with DES, it is biologically plausible that in utero exposures to exogenous estrogenic compounds are capable of reducing sperm production in adult men. However, the apparent existence of a maternal dose threshold for DES-induced effects on sperm counts undermines the likelihood that environmental estrogens, which are substantially less potent, are capable of causing similar effects. © 2013 Walter de Gruyter GmbH, Berlin/Boston Fisch Harry Department of Urology, Columbia University, 944 Park Ave., New York, NY 10028, USA aut Golden Robert Department of Urology, Columbia University, 944 Park Ave., New York, NY 10028, USA aut Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2181-2193 0033-4545 75:11-12<2181 2003 75 pac https://doi.org/10.1351/pac200375112181 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112181 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fisch Harry Department of Urology, Columbia University, 944 Park Ave., New York, NY 10028, USA aut NATIONALLICENCE 700 1- Golden Robert Department of Urology, Columbia University, 944 Park Ave., New York, NY 10028, USA aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2181-2193 0033-4545 75:11-12<2181 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter